The recent wide-spread adoption of single-cell profiling technologies has revealed that
individual cancers are not homogenous collections of deregulated cells, but instead …

Bioinformatics was first coined in 1970 to refer to information stored in biological systems. In
today's terms it has become synonymous with the generation and interrogation of large …

Cancer is presently valued as not just a profoundly heterogeneous pathology regarding cell
type and tissue beginning yet in addition as a sickness including deregulation of various …

The medical landscape is evolving at a rapid pace, creating the opportunity for more
personalized patient treatment and shifting the way healthcare is approached and thought …

Understanding Cancer from a Systems Biology Point of View: From Observation to Theory
and Back starts with a basic question, why do we sometimes observe accelerated metastatic …

Although the past few decades have seen great strides for cancer research, the molecular
pathogenesis of most solid tumors from many tissue types remains largely undefined. Most …

Cancer induction is a highly complex process involving hundreds of different inducers but
whose eventual outcome is the same. Clearly, it is essential to understand how signalling …

Background The genetic diversity of cancer and the dynamic interactions between
heterogeneous tumor cells, the stroma and immune cells present daunting challenges to the …

It's what we've all searched for at one time or another. That seemingly magical effect when
two plus two appears to add up to more than four. We search for it in datasets. We try to …

Introduction of high-throughput measurement technologies combined with the increase of
the scientific knowledge base, with respect to our understanding of cellular and biological …