The rapid and effective identification of pathogens in patients with pulmonary infections has
posed a persistent challenge in medicine, with conventional microbiological tests (CMTs) …

Objective To evaluate the value of nanopore targeted sequencing in diagnosing pneumonia
pathogens. Methods This large-scale multicentre prospective study performed in 8 hospitals …

Objective To evaluate the efficacy of targeted nanopore sequencing technology for the
detection of Mycobacterium tuberculosis (M. tb.) in bronchoalveolar lavage fluid (BALF) …

The gold standard for confirming bacterial infections is culture-positive, which has a long
sample-to-result turnaround time and poor sensitivity for unculturable and fastidious …

Respiratory tract infection (RTI) remains a significant cause of morbidity and mortality across
the globe. The optimal management of RTI relies upon timely pathogen identification via …

Background The clinical presentation of extrapulmonary tuberculosis (EPTB) is atypical and
it is easily confused with other diseases such as common infections, making prompt …

Background Diversified etiology of lower respiratory tract infection renders diagnosis
challenging. The mainstay microbial culture is time-consuming and constrained by variable …

Background It is common to obtain a low detection rate and unsatisfactory detection results
in complex infection or rare pathogen detection. This retrospective study aimed to illustrate …

This review provides an in-depth discussion of the development, principles and utility of
nanopore sequencing technology and its diverse applications in the identification of various …

Background Nanopore metagenomics has been used for infectious disease diagnosis for
bacterial pathogens. However, this technology currently lacks comprehensive performance …