Alzheimer's disease (AD) causes unrelenting, progressive cognitive impairments, but its
course is heterogeneous, with a broad range of rates of cognitive decline. The spread of tau …

Animal models of Alzheimer's disease have suggested that tau pathology propagation,
facilitated by amyloid pathology, may occur along connected pathways. To investigate these …

The coexistence of amyloid-β (Aβ) plaques and tau neurofibrillary tangles in the neocortex is
linked to neural system failure and cognitive decline in Alzheimer's disease. However, the …

Background Misfolding of microtubule-associated protein tau (MAPT) within neurons into
neurofibrillary tangles is an important pathological feature of Alzheimer's disease (AD). Tau …

Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and
neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also …

Non-neuronal responses in neurodegenerative disease have received increasing attention
as important contributors to disease pathogenesis and progression. Here we utilize single …

Tau and amyloid beta (Aβ) proteins accumulate along neuronal circuits in Alzheimer's
disease. Unraveling the genetic background for the regional vulnerability of these …

Amyloid plaques and neurofibrillary tangles co-occur in Alzheimer disease, but with different
topological and temporal patterns. Whether these two lesions are independent or …

In Alzheimer's diseases (AD), tau pathology is strongly associated with cognitive decline.
Preclinical evidence suggests that tau spreads across connected neurons in an activity …

Using spatial cell-type-enriched transcriptomics, we compare plaque-induced gene (PIG)
expression in microglia-touching plaques, neighboring plaques, and far from plaques in an …