The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has
accelerated research into the role of microglia in AD. While TREM2 mouse models have …

Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by
neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …

Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk
factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human …

Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of
extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary …

Polygenic risk scores have identified that genetic variants without genome‐wide significance
still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …

Abstract Background Disease-associated microglia (DAMs), that surround beta-amyloid
plaques, represent a transcriptionally-distinct microglial profile in Alzheimer's disease (AD) …

Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau
protein spreads from the entorhinal cortex to the hippocampal region early in the disease …

Loss-of-function TREM2 mutations strongly increase Alzheimer's disease (AD) risk. Trem2
deletion has revealed protective Trem2 functions in preclinical models of β-amyloidosis, a …

Microglia coordinate various functions in the central nervous system ranging from removing
synaptic connections, to maintaining brain homeostasis by monitoring neuronal function …

The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of
Alzheimer's disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting …