DA Nation, MD Sweeney, A Montagne, AP Sagare… - Nature medicine, 2019 - nature.com
Vascular contributions to cognitive impairment are increasingly recognized,,,–as shown by neuropathological,, neuroimaging,,,–, and cerebrospinal fluid biomarker, studies. Moreover …
Beta-amyloid deposition is a defining feature of Alzheimer's disease (AD). How genetic risk factors, like APOE and TREM2, intersect with cellular responses to beta-amyloid in human …
Alzheimer disease (AD) is a debilitating dementia believed to result from the deposition of extracellular amyloid-β (Aβ)-containing plaques followed by the formation of neurofibrillary …
Polygenic risk scores have identified that genetic variants without genome‐wide significance still add to the genetic risk of developing Alzheimer's disease (AD). Whether and how …
H Asai, S Ikezu, S Tsunoda, M Medalla, J Luebke… - Nature …, 2015 - nature.com
Accumulation of pathological tau protein is a major hallmark of Alzheimer's disease. Tau protein spreads from the entorhinal cortex to the hippocampal region early in the disease …
Microglia coordinate various functions in the central nervous system ranging from removing synaptic connections, to maintaining brain homeostasis by monitoring neuronal function …
The formation of hyperphosphorylated intracellular Tau tangles in the brain is a hallmark of Alzheimer's disease (AD). Tau hyperphosphorylation destabilizes microtubules, promoting …