Neurons are electrically excitable, postmitotic cells that perform sensory, relaying, and motor
functions. Because of their unique morphological and functional specialization, cells of this …

Previously thought of as a nonselective digestion process, autophagy is now known to
specifically degrade aggregated proteins and damaged cellular organelles through the …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein
complexes, and organelles through lysosomal degradation. The integrity of postmitotic …

The autophagy-lysosomal pathway is a major proteolytic pathway that in mammalian
systems mainly comprises of macroautophagy and chaperone-mediated autophagy. The …

Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic
contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove …

Highlights•Autophagy is a lysosomal degradation process essential for neuronal
survival.•Autophagy is a highly compartmentalized process in neurons.•Intercellular …

Autophagy is a tightly regulated cell self-eating process. It has been shown to be associated
with various neuropathological conditions and therefore, traditionally known as a stress …

Autophagy is a constitutive lysosomal catabolic pathway that degrades damaged organelles
and protein aggregates. Neuronal survival is highly dependent on autophagy due to its post …