Cornuside is an iridoid glycoside from Cornus officinalis, with the activities of anti-
inflammatory, antioxidant, anti-mitochondrial dysfunction, and neuroprotection. In the …

Background Treatment of mild-moderate Alzheimer's disease (AD) subjects (N= 119) for 52
weeks with the SIRT1 activator resveratrol (up to 1 g by mouth twice daily) attenuates …

Hesperetin is a bioactive flavonoid in the body, produced from hesperidin. No
comprehensive studies have shown its protective effects in neurodegenerative disorders …

J. Neurochem.(2012) 120, 461–472. Abstract Activation of microglia, the resident
macrophages of the brain, around the amyloid plaques is a key hallmark of Alzheimer's …

Background Neuroinflammation is a principal element in Alzheimer's disease (AD)
pathogenesis, so anti-inflammation may be a promising therapeutic strategy. Forsythoside B …

Background Neuroinflammation mediated by overactivated microglia plays a key role in
many neurodegenerative diseases, including Alzheimer's disease (AD). In this study, we …

Purpose Neurodegenerative diseases are associated with neuroinflammation along with
activation of microglia and oxidative stress, but currently lack effective treatments …

Background Macrophages play a dual role in neuroinflammatory disorders such as multiple
sclerosis (MS). They are involved in lesion onset and progression but can also promote the …

Alzheimer's disease, characterized by neuroinflammation and beta-amyloid protein plaques,
is a memory-threatening neurodegenerative disease with no effective treatment. Here, the …

There is accumulating evidence that the Ginkgo biloba extract EGb761 may help to prevent
Alzheimer's disease (AD). However, the underlying mechanism of its action remains to be …