A novel small-molecule agonist of PPAR-γ potentiates an anti-inflammatory M2 glial phenotype

GJ Song, Y Nam, M Jo, M Jung, JY Koo, W Cho… - …, 2016 - Elsevier
Neuroinflammation is a key process for many neurodegenerative diseases. Activated
microglia and astrocytes play an essential role in neuroinflammation by producing nitric …

Inhibition of TLR4 induces M2 microglial polarization and provides neuroprotection via the NLRP3 inflammasome in Alzheimer's disease

W Cui, C Sun, Y Ma, S Wang, X Wang… - Frontiers in …, 2020 - frontiersin.org
Accumulating evidence has indicated that activation of microglia and neuroinflammation
reaction play a prominent role in Alzheimer's disease (AD). Inhibition of toll-like receptor 4 …

PPAR-α agonist GW7647 protects against oxidative stress and iron deposit via GPx4 in a transgenic mouse model of Alzheimer's diseases

XX Qu, JH He, ZQ Cui, T Yang… - ACS chemical …, 2021 - ACS Publications
Alzheimer's disease (AD) is a neurodegenerative disease caused by lipid peroxidation and
iron hemostasis of the brain. PPAR-α is regarded as the most encouraging therapeutic …

Lychee seed polyphenol protects the blood–brain barrier through inhibiting Aβ (25–35)‐induced NLRP3 inflammasome activation via the AMPK/mTOR/ULK1 …

R Xiong, XG Zhou, Y Tang, JM Wu… - Phytotherapy …, 2021 - Wiley Online Library
Blood–brain barrier (BBB) dysfunction has been implicated in Alzheimer's disease (AD) and
is closely linked to the release of proinflammatory cytokines in brain capillary endothelial …

Diammonium Glycyrrhizinate Attenuates Aβ1–42‐Induced Neuroinflammation and Regulates MAPK and NF‐κB Pathways In Vitro and In Vivo

H Zhao, SL Wang, L Qian, JL Jin, H Li… - CNS neuroscience & …, 2013 - Wiley Online Library
Background and purpose Beta‐amyloid (A β)‐mediated inflammation contributes to the
progression and chronicity of A lzheimer's disease (AD), although the exact mechanism …

Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB

X Zhou, L Yuan, X Zhao, C Hou, W Ma, H Yu, R Xiao - Nutrition, 2014 - Elsevier
Objectives Microglia activation and neuroinflammation have been associated with the
pathogenesis of neurodegenerative disorders such as Alzheimer's disease (AD). Toll-like …

Quercetin improves cognitive disorder in aging mice by inhibiting NLRP3 inflammasome activation

H Li, FJ Chen, WL Yang, HZ Qiao, SJ Zhang - Food & Function, 2021 - pubs.rsc.org
Quercetin is one of the most abundant dietary flavonoid compounds, and its mechanism for
combating age-related neurodegenerative diseases is unclear. In this study, quercetin (35 …

Berberine suppresses amyloid-beta-induced inflammatory response in microglia by inhibiting nuclear factor-kappaB and mitogen-activated protein kinase signalling …

L Jia, J Liu, Z Song, X Pan, L Chen… - Journal of Pharmacy …, 2012 - academic.oup.com
Objectives The neuroinflammation induced by amyloid-beta peptide (A β) is one of the key
events in Alzheimer's disease (AD) progress in which microglia are the main cells involved …

Asiaticoside mitigates Alzheimer's disease pathology by attenuating inflammation and enhancing synaptic function

S Liu, L Chen, J Li, Y Sun, Y Xu, Z Li, Z Zhu… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the
accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of …

Targeting MAPK pathways by naringenin modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated cultures

B Zhang, YZ Wei, GQ Wang, DD Li, JS Shi… - Frontiers in cellular …, 2019 - frontiersin.org
Neuroinflammation is considered to be an important and inevitable pathological process
associated with all types of damages to, and disorders of, the central nervous system. The …