The Aurora family of serine/threonine kinases in mammals are key regulators of mitotic
progression and are commonly upregulated in human tumors. Since AURKA's increased …

Aurora kinases (AURKs) are serine/threonine protein kinases that play a critical role during
cell proliferation. Three isoforms of AURKs reported in mammals include AURKA, AURKB …

Background Enzymes belonging to the kinase family have been extensively implicated in
cancer. Aurora A (AURKA) is crucial in regulating the cell cycle. AURKA's significant role in …

Aurora kinases (AURKs) have been identified as promising biological targets for the
treatment of cancer. In this study, molecular dynamics simulations were employed to …

Aurora kinase A (AURKA) belongs to the family of serine/threonine kinases, whose
activation is necessary for cell division processes via regulation of mitosis. AURKA shows …

Abstract The Human Aurora Kinase (AURK) protein family is the key player of cell cycle
events including spindle assembly, kinetochore formation, chromosomal segregation …

Aurora kinase A (AURKA) is a normal cell proliferation-inducing enzyme encoded by
AURKA gene, with over-expression observed in different types of malignancies. Hence, the …

As a critical mitotic regulator, Aurora kinase A (AURKA) is aberrantly activated in a wide
range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of …

Aurora-A kinase (AURKA) belongs to the serine/threonine kinase family specific to cell
division. In normal cells, activation of the AURKA protein is essential for regulating …

Genetic alterations are lead causative agents behind the complex pathologies of cancers
which render all treatments unarmed. Such alterations in oncogenes can be treated by direct …