Background Lipid rafts are cholesterol and saturated lipid-rich, nanometer sized membrane
domains that are hypothesized to play an important role in compartmentalization and …

Lipid rafts are defined as detergent-resistant membrane microdomains of specific lipid and
protein composition. They are involved in many aspects of cell biology, including T-cell …

Background Lipid rafts present on the plasma membrane play an important role in
spatiotemporal regulation of cell signaling. Physical and chemical characterization of lipid …

Early “T cell activation” events are initiated within the lipid microenvironment of the plasma
membrane. Role of lipid membrane order (Lo) in spatiotemporal signaling through the …

Lipid rafts are important signaling platforms in T cells. Little is known about their properties in
human CD8+ T cells. We studied polarization of lipid rafts by digital immunofluorescence …

Membrane lipid microdomains (lipid rafts) play an important role in T cell function by forming
areas of high lipid order that facilitate activation. However, their role in regulating T cell …

Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol,
have been shown to function as signaling platforms in T cells. Surface raft expression is …

Plasma membrane lipids play essential roles in regulating T cell signaling, differentiation,
and effector functions. The major lipid species in the plasma membrane are …

Functional polarization of leukocytes is a requisite to accomplish immune function. Immune
synapse formation or chemotaxis requires asymmetric redistribution of membrane receptors …

The first appearance of lipid rafts, or lipid rafts-like structure, was occasionally observed by
cryo-electronic microscopy in 1980s as cavity, such as caveolae. However, the fully …