The introduction of the “maximum tolerated dose” in usual treatment protocols (and its
concomitant overt toxicity) made necessary the imposition of rest periods between cycles of …

Metronomic chemotherapy (MC) refers to the close administration of a chemotherapeutic
drug for a long time with no extended drug-free breaks. It was developed to overcome drug …

Purpose Over the past few years, more and more new selective molecules directed against
specific cellular targets have become available for cancer therapy, leading to impressive …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Metronomic chemotherapy, continuous and dose‐dense administration of chemotherapeutic
drugs with lowered doses, is being evaluated for substituting, augmenting, or appending …

Simple Summary The present article reviews the state of the art of metronomic
chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung …

Conventional cytotoxic anticancer chemotherapeutic drugs were developed with the intent of
treating cancer by direct killing or inhibition of growth of cycling tumour cells. Recently …

Metronomic chemotherapy is a low dosing treatment strategy that attracts growing scientific
and clinical interest. It refers to dense and uninterrupted administration of low doses of …

Metronomic chemotherapy refers to the close, regular administration of comparatively low
doses of cytotoxic drugs, with minimal or no drug-free breaks, over prolonged periods. It is …

We present a rationale for further clinical development and assessment of metronomic
chemotherapy on the basis of unexpected results obtained in translational mouse models of …