The normal pH in blood and extracellular fluid at 37OC is 7.40. The pH inside ordinary
muscle cells is 7.00 at the same temperature (1, 2, 3). Proteins are ionized in just this pH …

CO is absorbed from the environment, CO analytical methods. later demonstrated small
amounts of CO Page 1 Journal of Clinical Investigation Vol. 42, No. 7, 1963 ENDOGENOUS …

Carbon monoxide is exhaled constantly in low concentrations with the expired air in man as
well as in those animals, i. e;, dogs and rabbits, that have hitherto been examined in this …

THE body's desire and ability to maintain homeostasis with respect to the pH and COs
tension of its arterial blood plasma has long been recognized and experimentally …

IT has been known since the late nineteenth century that blood of man and animals contains
small quantities of carbon monoxide (CO) 1; however, only in relatively recent years has it …

The maintenance of equilibrium by an adult individual, more specifically the maintenance of
a steady state, has been recognized as a chief characteristic of life and a cardinal principle …

It has now been over 20 years since the first demonstration that CO is endog enously
produced in normal man (Sjostrand 1). Methods of accurately measuring CO production in …

FIGURE 1. Carbon dioxide dissociation curves of frog nerve, muscle, and blood. The
experimental points apply to the nerve curve. Reproduced by permission from Medicine …

The localization of carbon monoxide in the tissues of man and animals remains a basic
problem for study. It is clear that most of the body CO stores are found in blood chemically …

In the course of a study of the electrolyte distribution in tissues, the need arose for a simple
method of determining the COs content of portions of fresh tissue. Such a method adapted …