The hereditary deficiency of antioxidant enzymes when associated with sickle cell anemia
(SCA) further contributes to the oxidation of hemoglobin S, which increases the formation of …

Objectives Clinical manifestations of sickle cell disease (SCD) result from sickling of Hb S
due to oxidation, which is augmented by accumulation of oxygen-free radicals. Deficiencies …

Glutathione S-transferase gene deletions are known detoxification agents and cause
oxidative damage. In different studies, variations in null allele frequency have been …

Sickle cell disease (SCD) complications are associated with oxidative stress. Glutathione S-
transferases (GSTs) are a group of enzymes that protect against oxidative stress. The aims …

Background: Glutathione system plays an important role in the protection of cells and tissue
against damage from oxidative stress. Impairment of the glutathione system due to genetic …

This study evaluated the oxidative stress and antioxidant capacity markers in sickle cell
anemia (SCA) patients with and without treatment with hydroxyurea. We assessed GSTT1 …

BACKGROUND: Glutathione S-transferase gene deletions are known detoxification agents
and cause oxidative damage. Due to the different pathophysiology of anemia in thalassemia …

Sickle cell anemia (SCA) is a hereditary disorder with higher potential for oxidative damage
due to chronic redox imbalance in red cells. We measured antioxidant enzymes including …

To find the influence of genetic polymorphisms of glutathione S-transferases M1 (GSTM1)
and T1 (GSTT1) on hematological parameters in smoker and non-smoker subjects, the …

This work aimed at studying a possible influence of methylenetetrahydrofolate reductase
(MTHFR; c. 677C> T) and cystathionine β-synthase (CBS; 844ins68) polymorphisms on …