A two-stage “tandem strategy” for the synthesis of indoles with a high level of substitution on
the six-membered ring is described. Benzannulation based on the reaction of …

A two-stage “tandem strategy” for the regiocontrolled synthesis of very highly substituted
quinolines is described. Benzannulation based on the reaction of cyclobutenones or diazo …

Ynamides react with conjugated enynes in intramolecular [4+ 2] cycloadditions to afford
substituted indolines that undergo oxidation with o-chloranil to furnish the corresponding …

4-Chloro-2, 3-disubstituted-2-cyclobutenones undergo palladium-catalyzed cross-coupling
with oxygen and sulfur heteroaryl tin reagents, and uponthermolysis at 100 C, good to high …

The reaction of amines with 2, 3-bis (phenylsulfonyl)-1, 3-butadiene affords pyrrolidines in
high yield. The formation of the nitrogen heterocycle involves initial conjugate addition and …

The α-alkylation of deprotonated Strecker products derived from primary amines and
aromatic aldehydes with 2-halobenzyl halides furnishes intermediates that can be cyclized …

A directed C− H bond activation approach to the synthesis of indans, tetralins, dihydrofurans,
dihydroindoles, and other polycyclic aromatic compounds is presented. Cyclization of …

A general strategy for thesynthesis of highly substituted polycyclic aromatic and
heteroaromatic compounds has been developed. The new aromatic annulation is …

A general procedure for the palladium-catalyzed annulation of substituted haloanilines with
norbornadiene gives functionalized indolines in 51− 98% yield. These indolines can be …

Aminobenzaldehydes react with indoles in an unprecedented cascade reaction. This acid-
catalyzed redox-neutral annulation proceeds via a condensation/1, 5-hydride shift/ring …