Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Fully
penetrant (causal) mutations leading to predominantly early-onset familial AD have been …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

Genetic factors play a major role in determining a person's risk to develop Alzheimer's
disease (AD). Rare mutations transmitted in a Mendelian fashion within affected families, for …

Since the 1990s, the genetics of Alzheimer disease (AD) has been an active area of
research. The identification of deterministic mutations in the APP, PSEN1, and PSEN2 …

Genetically, Alzheimer's disease is heterogeneous and complex and in most cases displays
no single or simple mode of inheritance. Early‐onset familial forms of Alzheimer's disease …

Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Alzheimer's disease (AD) is a genetically complex disease whose pathogenesis is largely
influenced by genetic factors. Three decades of intensive research have yielded four …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Alzheimer's disease (AD) is a complex disorder of the central nervous system (CNS).
Molecular genetic research has provided a wealth of information regarding the genetic …

Alzheimer disease (AD), the major form of senile dementia, is rapidly becoming a major
health problem in developed countries since as populations live longer the number of …