[HTML][HTML] Guidelines for genome-wide association studies

GS Barsh, GP Copenhaver, G Gibson… - PLoS genetics, 2012 - journals.plos.org
Genome-wide association studies (GWAS) have revolutionized human genetics. They have
led to the identification of thousands of loci that affect both normal variation and susceptibility …

[PDF][PDF] Prioritizing GWAS results: a review of statistical methods and recommendations for their application

RM Cantor, K Lange, JS Sinsheimer - The American Journal of Human …, 2010 - cell.com
Genome-wide association studies (GWAS) have rapidly become a standard method for
disease gene discovery. A substantial number of recent GWAS indicate that for most …

[HTML][HTML] Genome-wide association studies

E Uffelmann, QQ Huang, NS Munung… - Nature Reviews …, 2021 - nature.com
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …

Genome-wide association studies: hypothesis-“free” or “engaged”?

GD Kitsios, E Zintzaras - Translational Research, 2009 - Elsevier
The advent of the first wave of genome-wide association studies (GWAS) provided a new
conceptual framework in the search for variants underlying common disorders: a massive …

Benefits and limitations of genome-wide association studies

V Tam, N Patel, M Turcotte, Y Bossé, G Paré… - Nature Reviews …, 2019 - nature.com
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

[HTML][HTML] Homogeneous case subgroups increase power in genetic association studies

M Traylor, H Markus, CM Lewis - European Journal of Human Genetics, 2015 - nature.com
Genome-wide association studies of clinically defined cases against controls have
transformed our understanding of the genetic causes of many diseases. However, there are …

[HTML][HTML] GWAS Central: a comprehensive resource for the comparison and interrogation of genome-wide association studies

T Beck, RK Hastings, S Gollapudi, RC Free… - European journal of …, 2014 - nature.com
To facilitate broad and convenient integrative visualization of and access to GWAS data, we
have created the GWAS Central resource (http://www. gwascentral. org). This database …

Bringing genome-wide association findings into clinical use

TA Manolio - Nature Reviews Genetics, 2013 - nature.com
Genome-wide association studies (GWASs) have been heralded as a major advance in
biomedical discovery, having identified~ 2,000 robust associations with complex diseases …

[HTML][HTML] Rare variants create synthetic genome-wide associations

SP Dickson, K Wang, I Krantz, H Hakonarson… - PLoS …, 2010 - journals.plos.org
Genome-wide association studies (GWAS) have now identified at least 2,000 common
variants that appear associated with common diseases or related traits (http://www. genome …

Genome-wide association studies: past, present and future

MI McCarthy, JN Hirschhorn - Human molecular genetics, 2008 - academic.oup.com
When the time came to decide on the topic for the next in the series of Human Molecular
Genetics reviews, on this occasion, there was little need for debate. The advent of genome …