Objective: High comorbidity among psychiatric disorders suggests that they may share
underlying neurobiological deficits. Abnormalities in cortical thickness and volume have …

Background An emerging body of literature has indicated that broad, transdiagnostic
dimensions of psychopathology are associated with alterations in brain structure across the …

Childhood is an important time for the manifestation of psychopathology. Psychopathology is
characterized by considerable comorbidity which is mirrored in the underlying neural …

Objective: Psychiatric symptomatology during childhood predicts persistent mental illness
later in life. While neuroimaging methodologies are routinely applied cross-sectionally to the …

Objective A general psychopathology (p) factor captures shared variation across mental
disorders. Structural neural alterations have been associated with the p factor concurrently …

Objective Adults with established diagnoses of serious mental illness (bipolar disorder and
schizophrenia) exhibit structural brain abnormalities, yet less is known about how such …

Importance Structural brain abnormalities are prominent in psychotic disorders, including
schizophrenia. However, it is unclear when aberrations emerge in the disease process and …

Objective In both children and adults, psychiatric illness is associated with structural brain
alterations, particularly in the prefrontal cortex (PFC). However, most studies compare gray …

Background The spatial layout of large-scale functional brain networks differs between
individuals and is particularly variable in the association cortex, implicated in a broad range …

Importance Many mental disorders emerge during adolescence, which may reflect a cost of
the potential for brain plasticity offered during this period. Brain dysconnectivity has been …