Angiogenesis, the growth of new capillaries from preexisting blood vessels, is a complex
process involving endothelial cell (EC) activation, disruption of vascular basement …

Galectin-9 consists of two peptide-linked carbohydrate recognition domains (CRDs), but
alternative splicing and proteolytic processing can give rise to multiple galectin-9 isoforms …

Abstract Galectin-8 (gal-8) is a “tandem-repeat”-type galectin, containing two carbohydrate
recognition domains connected by a linker peptide. gal-8 is expressed both in the cytoplasm …

The growth of new blood vessels out of the pre-existing vasculature, ie, angiogenesis, is
executed by endothelial cells that normally form the inner lining of blood vessels. During …

Galectin-3 plays an important role in endothelial morphogenesis and angiogenesis. We
investigated the endocytosis of galectin-3 in human vascular endothelial cells and showed …

Angiogenesis, the growth of new blood vessels out of existing vessels, is a complex and
tightly regulated process. It is executed by the cells that cover the inner surface of the …

Abstract Galectin-1 (Gal-1) is a β-galactoside-binding lectin that regulates endothelial cell
migration, proliferation, and adhesion. However, the effect of Gal-1 on vascular permeability …

Increasing evidence suggests that carbohydrate-binding proteins play an essential role in
tumor growth and metastasis. However, conflicting results on their function in the regulation …

Recent studies have shown that a carbohydrate-binding protein, galectin-3, is a novel pro-
angiogenic molecule. The mechanism by which galectin-3 promotes angiogenesis remains …

Tumor angiogenesis is a key event in cancer progression. Here, we report that tumors can
stimulate tumor angiogenesis by secretion of galectin-1. Tumor growth and tumor …