Cytokine storm syndrome

RQ Cron, G Goyal, WW Chatham - Annual Review of Medicine, 2023 - annualreviews.org
Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention
with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions …

[HTML][HTML] Cytokine storm

DC Fajgenbaum, CH June - New England Journal of Medicine, 2020 - Mass Medical Soc
Cytokine Storm Cytokine storm, a life-threatening disorder involving cytokine elevations and
immune-cell hyperactivation, has various causes and is characterized by constitutional …

[HTML][HTML] Macrophage activation-like syndrome: a distinct entity leading to early death in sepsis

E Karakike, EJ Giamarellos-Bourboulis - Frontiers in immunology, 2019 - frontiersin.org
Hemophagocytic lymphohistocytosis (HLH) is characterized by fulminant cytokine storm
leading to multiple organ dysfunction and high mortality. HLH is classified into familial …

[图书][B] Cytokine storm syndrome

RQ Cron, EM Behrens - 2019 - Springer
This textbook was necessitated by the broadening recognition of cytokine storm syndromes
(CSS) and their import and impact on health worldwide. We dedicate this to the clinicians …

Highways to hell: Mechanism-based management of cytokine storm syndromes

SW Canna, RQ Cron - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Since the first textbook devoted to cytokine storm syndromes (CSSs) was published in 2019,
the world has changed dramatically and the term's visibility has broadened. Herein, we …

The genetics of macrophage activation syndrome

GS Schulert, RQ Cron - Genes & Immunity, 2020 - nature.com
Macrophage activation syndrome (MAS), or secondary hemophagocytic lymphohistiocytosis
(HLH), is a cytokine storm syndrome associated with multi-organ system dysfunction and …

Clinical features of cytokine storm syndrome

M Shimizu - Cytokine storm syndrome, 2019 - Springer
The common clinical features of cytokine storm syndrome (CSS) are sustained fever,
splenomegaly, hepatomegaly with liver dysfunction, lymphadenopathy, coagulopathy …

JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation

LK Meyer, KC Verbist, S Albeituni… - Blood, The Journal …, 2020 - ashpublications.org
Cytokine storm syndromes (CSS) are severe hyperinflammatory conditions characterized by
excessive immune system activation leading to organ damage and death. Hemophagocytic …

Cytokine storm syndrome: looking toward the precision medicine era

EM Behrens, GA Koretzky - Arthritis & rheumatology, 2017 - Wiley Online Library
“Cytokine storm syndrome” is a diverse set of conditions unified by a clinical phenotype of
systemic inflammation, multi-organ failure, hyperferritinemia, and, if untreated, often death …

[HTML][HTML] Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome

P Mehta, RQ Cron, J Hartwell, JJ Manson… - The Lancet …, 2020 - thelancet.com
The term cytokine storm syndromes describes conditions characterised by a life-threatening,
fulminant hypercytokinaemia with high mortality. Cytokine storm syndromes can be genetic …