The vacuolar ATPases are ATP-dependent proton pumps whose functions include the
acidification of intracellular compartments and the extrusion of protons through the cell …

Cancer cells show a metabolic shift that makes them overproduce protons; this has the
potential to disturb the cellular acidbase homeostasis. However, these cells show …

Tumor cells in vivo often exist in a hypoxic microenvironment with a lower extracellular pH
than that surrounding normal cells. Ability to upregulate proton extrusion may be important …

Resistance to cytotoxic agents is a major problem in treating cancer. The mechanisms
underlying this phenomenon appear to take advantage of functions involved in the control of …

Tumor microenvironment may play a key role in tumor malignancy. It is hypothesized that
hypoxia and acidity may contribute to the progression from benign to malignant growth. In …

Proton pumps like the vacuolar-type H+ ATPase (V-ATPase) are involved in the control of
cellular pH in normal and tumor cells. Treatment with proton pump inhibitors (PPI) induces …

Recent evidence has reported that proton pump inhibitors (PPIs) can exert antineoplastic
effects through the disruption of pH homeostasis by inhibiting vacuolar ATPase (H+ …

Growing evidence suggests a key role of tumor acidic microenvironment in cancer
development, progression, and metastasis. As a consequence, the need for compounds that …

Upregulation of proton extrusion is critical for tumor cell survival in an ischemic
microenvironment with a lower extracellular pH (pHe). Lower pHe and higher intracellular …

Abstract Vacuolar ATPase (V‐ATPase) is an ATP‐dependent H+‐transporter that pumps
protons across intracellular and plasma membranes. It consists of a large multi‐subunit …