Single-cell multi-omics sequencing of human early embryos
DNA methylation, chromatin states and their interrelationships represent critical epigenetic
information, but these are largely unknown in human early embryos. Here, we apply single …
information, but these are largely unknown in human early embryos. Here, we apply single …
[HTML][HTML] Gene expression atlas for human embryogenesis
H Yi, L Xue, MX Guo, J Ma, Y Zeng, W Wang… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Human embryogenesis is believed to involve an integrated set of complex yet coordinated
development of different organs and tissues mediated by the changes in the spatiotemporal …
development of different organs and tissues mediated by the changes in the spatiotemporal …
Single-cell RNA-seq analysis of mouse preimplantation embryos by third-generation sequencing
The development of next generation sequencing (NGS) platform-based single-cell RNA
sequencing (scRNA-seq) techniques has tremendously changed biological researches …
sequencing (scRNA-seq) techniques has tremendously changed biological researches …
Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles
F Licciardi, T Lhakhang, YG Kramer, Y Zhang… - Scientific reports, 2018 - nature.com
Unveiling the transcriptome of human blastocysts can provide a wealth of important
information regarding early embryonic ontology. Comparing the mRNA production of …
information regarding early embryonic ontology. Comparing the mRNA production of …
Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under …
MSH Ko, TA Threat, X Wang, JH Horton… - Human molecular …, 1998 - academic.oup.com
Mammalian embryos can only survive if they attach to the uterus (implantation) and establish
proper maternal-fetal interactions. To understand this complex implantation pathway, we …
proper maternal-fetal interactions. To understand this complex implantation pathway, we …
An integrative transcriptomic atlas of organogenesis in human embryos
Human organogenesis is when severe developmental abnormalities commonly originate.
However, understanding this critical embryonic phase has relied upon inference from patient …
However, understanding this critical embryonic phase has relied upon inference from patient …
Functional profiling of stage-specific proteome and translational transition across human pre-implantation embryo development at a single-cell resolution
Dear Editor, Pre-implantation development is the first step in giving rise to a new life. The
landscape of epigenomic 1, 2 and transcriptomic 3, 4 regulation during human …
landscape of epigenomic 1, 2 and transcriptomic 3, 4 regulation during human …
Single-cell transcriptome analysis of uniparental embryos reveals parent-of-origin effects on human preimplantation development
L Leng, J Sun, J Huang, F Gong, L Yang, S Zhang… - Cell stem cell, 2019 - cell.com
To investigate the contribution of parental genomes to early embryogenesis, we profiled the
single-cell transcriptomes of human biparental and uniparental embryos systematically from …
single-cell transcriptomes of human biparental and uniparental embryos systematically from …
Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early …
Preimplantation embryogenesis encompasses several critical events including genome
reprogramming, zygotic genome activation (ZGA), and cell-fate commitment. The molecular …
reprogramming, zygotic genome activation (ZGA), and cell-fate commitment. The molecular …
[HTML][HTML] Integrated pseudotime analysis of human pre-implantation embryo single-cell transcriptomes reveals the dynamics of lineage specification
Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …
gateway to improving assisted reproductive technologies and stem cell research. Here we …