The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …

NSP14 is a dual function enzyme containing an N-terminal exonuclease domain (ExoN) and
C-terminal Guanine-N7-methyltransferase (N7-MTase) domain. Both activities are essential …

During RNA replication, coronaviruses require proofreading to maintain the integrity of their
large genomes. Nsp14 associates with viral polymerase complex to excise the mismatched …

SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …

The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-
CoV-2 belongs to an order, Nidovirale s, with very large RNA genomes. It is proposed that …

Nsp15, a uridine specific endoribonuclease conserved across coronaviruses, processes
viral RNA to evade detection by host defense systems. Crystal structures of Nsp15 from …

Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus
Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global …

SARS-CoV-2is the causative agent for the ongoing COVID19 pandemic, and this virus
belongs to the Coronaviridae family. The nsp14 protein of SARS-CoV-2 houses a 3′ to 5 …

The unexpected outbreak of a novel human coronavirus infection has imposed great threat
to public health. Thus far, this newly-identified virus has spread to 215 countries and …