Regime-separated approach for population balance modelling of continuous wet granulation of pharmaceutical formulations
A two-dimensional population balance model (PBM) was developed in order to predict
granule size distribution (GSD) in continuous twin-screw granulation. The model predicts the …
granule size distribution (GSD) in continuous twin-screw granulation. The model predicts the …
Numerical methods for solving two-dimensional aggregation population balance equations
The cell average technique (CAT) and the fixed pivot (FP) method for solving two-
dimensional aggregation population balance equations using a rectangular grid were …
dimensional aggregation population balance equations using a rectangular grid were …
An efficient numerical technique for solving population balance equation involving aggregation, breakage, growth and nucleation
J Kumar, M Peglow, G Warnecke, S Heinrich - Powder Technology, 2008 - Elsevier
A new discretization for simultaneous aggregation, breakage, growth and nucleation is
presented. The new discretization is an extension of the cell average technique developed …
presented. The new discretization is an extension of the cell average technique developed …
Multi-scale modeling of granulation processes: Bi-directional coupling of PBM with DEM via collision frequencies
D Barrasso, R Ramachandran - Chemical Engineering Research and …, 2015 - Elsevier
Wet granulation is a complex particle design process often operated inefficiently in industrial
applications. Enhanced process understanding is required to facilitate design, control, and …
applications. Enhanced process understanding is required to facilitate design, control, and …
Development of a multi-compartment population balance model for high-shear wet granulation with discrete element method
This paper presents a multi-compartment population balance model for wet granulation
coupled with DEM (discrete element method) simulations. Methodologies are developed to …
coupled with DEM (discrete element method) simulations. Methodologies are developed to …
Limitations of one-dimensional population balance models of wet granulation processes
SM Iveson - Powder Technology, 2002 - Elsevier
Most traditional models of wet granulation processes use one-dimensional population
balances, which assume that granule size is the only independent granule property that …
balances, which assume that granule size is the only independent granule property that …
On the modelling of granule size distributions in twin-screw wet granulation: Calibration of a novel compartmental population balance model
In recent years, novel developments in the continuous manufacturing of solid dosage forms
using twin-screw wet granulation have grasped the attention of the pharmaceutical industry …
using twin-screw wet granulation have grasped the attention of the pharmaceutical industry …
A reduced order PBM–ANN model of a multi-scale PBM–DEM description of a wet granulation process
D Barrasso, A Tamrakar, R Ramachandran - Chemical Engineering …, 2014 - Elsevier
Wet granulation is a particle design process, often used in the pharmaceutical, consumer
product, food, and fertilizer industries. A better process understanding is needed to improve …
product, food, and fertilizer industries. A better process understanding is needed to improve …
Linking discrete particle simulation to continuum process modelling for granular matter: Theory and application
Two approaches are widely used to describe particle systems: the continuum approach at
macroscopic scale and the discrete approach at particle scale. Each has its own advantages …
macroscopic scale and the discrete approach at particle scale. Each has its own advantages …
Population balance modelling to describe the particle aggregation process: A review
Unit operations used to achieve solid-liquid separation for fine particle suspensions rely
upon efficient aggregate formation. There is considerable potential for predictions from …
upon efficient aggregate formation. There is considerable potential for predictions from …