Preparation of exosomes for siRNA delivery to cancer cells

FN Faruqu, L Xu, KT Al-Jamal - JoVE (Journal of Visualized Experiments), 2018 - jove.com
Extracellular vesicles, in particular exosomes, have recently gained interest as novel drug
delivery vectors due to their biological origin, abundance, and intrinsic capability in …

Functional exosome-mimic for delivery of siRNA to cancer: in vitro and in vivo evaluation

Z Yang, J Xie, J Zhu, C Kang, C Chiang, X Wang… - Journal of Controlled …, 2016 - Elsevier
Exosomes, the smallest subgroup of extracellular vesicles, have been recognized as
extracellular organelles that contain genetic and proteomic information for long distance …

Exosomes are natural carriers of exogenous siRNA to human cells in vitro

TA Shtam, RA Kovalev, EY Varfolomeeva… - Cell Communication and …, 2013 - Springer
Background Exosomes are nano-sized vesicles of endocytic origin that are involved in cell-
to-cell communication including shuttle RNA, mainly mRNA and microRNA. As exosomes …

[PDF][PDF] Exosomes as nanocarriers for siRNA delivery: paradigms and challenges

F Shahabipour, M Banach, A Sahebkar - Archives of Medical Science, 2016 - termedia.pl
Exosomes are nano-sized vesicles that facilitate intercellular communications through
carrying genetic materials and functional biomolecules. Owing to their unique size and …

Exosomes: cell-created drug delivery systems

A Familtseva, N Jeremic, SC Tyagi - Molecular and cellular biochemistry, 2019 - Springer
Abstract Exosomes are 40-to 100-nm cell-originated vesicles derived from endocytic
compartments that are released into almost all biological fluids. Exosomes are cell-created …

Delivery of small interfering RNAs to cells via exosomes

J Wahlgren, L Statello, G Skogberg, E Telemo… - SiRNA Delivery Methods …, 2016 - Springer
Exosomes are small membrane bound vesicles between 30 and 100 nm in diameter of
endocytic origin that are secreted into the extracellular environment by many different cell …

Exosome as a delivery vehicle for cancer therapy

B Moon, S Chang - Cells, 2022 - mdpi.com
Exosomes are small extracellular vesicles that are naturally produced and carry
biomolecules such as proteins, microRNAs, and metabolites. Because of their small size …

Exosomes: a role for naturally occurring nanovesicles in cancer growth, diagnosis and treatment

A Srivastava, J Filant, K M. Moxley, A Sood… - Current gene …, 2015 - benthamdirect.com
Exosomes are 30-100 nm bodies secreted from almost all types of cells into the extracellular
spaces. They enclose in their lumen active genetic information in the form of messenger …

Targeted delivery of exosomes armed with anti-cancer therapeutics

H Choi, H Yim, C Park, SH Ahn, Y Ahn, A Lee, H Yang… - Membranes, 2022 - mdpi.com
Among extracellular vesicles, exosomes have gained great attention for their role as
therapeutic vehicles for delivering various active pharmaceutical ingredients (APIs) …

A review on the use of extracellular vesicles for the delivery of drugs and biological therapeutics

SJ Amina, T Azam, F Dagher, B Guo - Expert Opinion on Drug …, 2024 - Taylor & Francis
Introduction Exosomes, a type of extracellular vesicles, are effective tools for delivering small-
molecule drugs and biological therapeutics into cells and tissues. Surface modifications with …