Nearly all human complex traits and disease phenotypes exhibit some degree of sex
differences, including differences in prevalence, age of onset, severity or disease …

Understanding the genetic architecture of disease is an enormous challenge, and should be
guided by evolutionary principles. Recent studies in evolutionary genetics show that sexual …

Background The prevalence of several human morbid phenotypes is sometimes much
higher than intuitively expected. This can directly arise from the presence of two sexes, male …

Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of
many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence …

Common diseases often show sex differences in prevalence, onset, symptomology,
treatment, or prognosis. Although studies have been performed to evaluate sex differences …

Males and females have obvious phenotypic differences; they also exhibit differences
related to health, life span, cognitive abilities and have different responses to diseases such …

The role of sex in biomedical studies has often been overlooked, despite evidence of
sexually dimorphic effects in some biological studies. Here, we used high-throughput …

Males and females present differences in complex traits and in the risk of a wide array of
diseases. Genotype by sex (GxS) interactions are thought to account for some of these …

The severity and prevalence of many diseases are known to differ between the sexes. Organ
specific sex-biased gene expression may underpin these and other sexually dimorphic …

Males and females display differences in physiology, behaviour and susceptibility to many
diseases. Genome-wide transcription profiling studies have uncovered large-scale sex …