A single-cell atlas of the peripheral immune response in patients with severe COVID-19
There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Single-cell landscape of immunological responses in patients with COVID-19
JY Zhang, XM Wang, X Xing, Z Xu, C Zhang… - Nature …, 2020 - nature.com
Abstract In coronavirus disease 2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
syndrome coronavirus 2 (SARS-CoV-2) infection, the relationship between disease severity …
Global absence and targeting of protective immune states in severe COVID-19
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
pleiotropic and systemic effects in some individuals,–, many others experience milder …
pleiotropic and systemic effects in some individuals,–, many others experience milder …
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
INTRODUCTION Many patients with coronavirus disease 2019 (COVID-19), caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, present with …
[HTML][HTML] Longitudinal analyses reveal immunological misfiring in severe COVID-19
Recent studies have provided insights into the pathogenesis of coronavirus disease 2019
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
(COVID-19),,–. However, the longitudinal immunological correlates of disease outcome …
Single-cell RNA sequencing of blood antigen-presenting cells in severe COVID-19 reveals multi-process defects in antiviral immunity
M Saichi, MZ Ladjemi, S Korniotis, C Rousseau… - Nature Cell …, 2021 - nature.com
COVID-19 can lead to life-threatening respiratory failure, with increased inflammatory
mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high …
mediators and viral load. Here, we perform single-cell RNA-sequencing to establish a high …
[HTML][HTML] COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas
A dysfunctional immune response in coronavirus disease 2019 (COVID-19) patients is a
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
recurrent theme impacting symptoms and mortality, yet a detailed understanding of pertinent …
[HTML][HTML] Cell-type-specific immune dysregulation in severely ill COVID-19 patients
Recent studies have demonstrated immunologic dysfunction in severely ill coronavirus
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
disease 2019 (COVID-19) patients. We use single-cell RNA sequencing (scRNA-seq) to …
A dynamic COVID-19 immune signature includes associations with poor prognosis
Improved understanding and management of COVID-19, a potentially life-threatening
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …
disease, could greatly reduce the threat posed by its etiologic agent, SARS-CoV-2. Toward …