Polygenic risk scores (PRSs) developed from multi-ancestry genome-wide association
studies (GWASs), PRS multi, hold promise for improving PRS accuracy and generalizability …

Polygenic risk scores (PRS) are on course to translate the results of genome-wide
association studies (GWAS) into clinical practice. To date, most GWAS have been based on …

Abstract Polygenic Risk Scores (PRS) have huge potential to contribute to biomedical
research and to a future of precision medicine, but to date their calculation relies largely on …

Polygenic risk scores (PRSs) have wide applications in human genetics research, but often
include tuning parameters which are difficult to optimize in practice due to limited access to …

Polygenic risk scores (PRS) have attenuated cross-population predictive performance. As
existing genome-wide association studies (GWAS) have been conducted predominantly in …

As most existing genome-wide association studies (GWAS) were conducted in European
ancestry cohorts and as the existing PRS models have limited transferability across ancestry …

As most existing genome-wide association studies (GWASs) were conducted in European-
ancestry cohorts, and as the existing polygenic risk score (PRS) models have limited …

Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that
leverages shared genetic effects across ancestries to increase PRS portability. We evaluate …

Great efforts are being made to develop advanced polygenic risk scores (PRS) to improve
the prediction of complex traits and diseases. However, most existing PRS are primarily …

Motivation As increasing sample sizes from genome-wide association studies (GWASs),
polygenic risk scores (PRSs) have shown great potential in personalized medicine with …