Inflammasome activation at the crux of severe COVID-19

SM Vora, J Lieberman, H Wu - Nature Reviews Immunology, 2021 - nature.com
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2), results in life-threatening disease in a minority of patients, especially elderly …

Inflammasomes and IL-1 family cytokines in SARS-CoV-2 infection: from prognostic marker to therapeutic agent

J Declercq, E De Leeuw, BN Lambrecht - Cytokine, 2022 - Elsevier
Despite global vaccination programs, infections with severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) continue to cause severe disease with significant morbidity …

Inflammasomes: a rising star on the horizon of COVID-19 pathophysiology

M Wang, F Yu, W Chang, Y Zhang, L Zhang… - Frontiers in …, 2023 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a contagious respiratory
virus that is the cause of the coronavirus disease 2019 (COVID-19) pandemic which has …

Inflammasomes and pyroptosis as therapeutic targets for COVID-19

JKY Yap, M Moriyama, A Iwasaki - The Journal of Immunology, 2020 - journals.aai.org
The inflammatory response to severe acute respiratory syndrome–related coronavirus 2
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …

Inflammasomes are activated in response to SARS-CoV-2 infection and are associated with COVID-19 severity in patients

TS Rodrigues, KSG de Sá, AY Ishimoto… - Journal of Experimental …, 2021 - rupress.org
Severe cases of COVID-19 are characterized by a strong inflammatory process that may
ultimately lead to organ failure and patient death. The NLRP3 inflammasome is a molecular …

Inflammasomes and SARS-CoV-2 infection

J Kaivola, TA Nyman, S Matikainen - Viruses, 2021 - mdpi.com
SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The
disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 …

The inflammasome in times of COVID-19

JC de Rivero Vaccari, WD Dietrich, RW Keane… - Frontiers in …, 2020 - frontiersin.org
Coronaviruses (CoVs) are members of the genus Betacoronavirus and the Coronaviridiae
family responsible for infections such as severe acute respiratory syndrome (SARS), Middle …

Inflammasome activation by SARS-CoV-2 and its participation in COVID-19 exacerbation

TS Rodrigues, DS Zamboni - Current Opinion in Immunology, 2023 - Elsevier
Highlights•SARS-CoV-2 infection in vitro triggers activation of the NLRP3
inflammasome.•The NLRP3 is activated in mice infected with SARS-CoV-2 and in the lungs …

SARS-CoV-2 engages inflammasome and pyroptosis in human primary monocytes

AC Ferreira, VC Soares… - Cell death …, 2021 - nature.com
Infection by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been
associated with leukopenia and uncontrolled inflammatory response in critically ill patients …

Targeting the NLRP3 inflammasome in severe COVID-19

TL Freeman, TH Swartz - Frontiers in immunology, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …