For 3D bioprinted tissues to be scaled-up to clinically relevant sizes, effective
prevascularisation strategies are required to provide the necessary nutrients for normal …

Bone tissue engineers are facing a daunting challenge when attempting to fabricate bigger
constructs intended for use in the treatment of large bone defects, which is the …

Large bone defects remain an unsolved clinical challenge because of the lack of effective
vascularization in newly formed bone tissue. 3D bioprinting is a fabrication technology with …

Fabricating 3D large‐scale bone tissue constructs with functional vasculature has been a
particular challenge in engineering tissues suitable for repairing large bone defects. To …

Vascularization has a pivotal role in engineering successful tissue constructs. However, it
remains a major hurdle of bone tissue engineering, especially in clinical applications for the …

Vascularization is a fundamental prerequisite for large bone construct development and
remains one of the main challenges of bone tissue engineering. Our current study presents …

Vascularization plays a crucial role in bone formation and regeneration process.
Development of a functional vasculature to improve survival and integration of tissue …

Vascularization in bone tissues is essential for the distribution of nutrients and oxygen, as
well as the removal of waste products. Fabrication of tissue-engineered bone constructs with …

Organ or tissue printing, a novel approach in tissue engineering, creates layered, cell-laden
hydrogel scaffolds with a defined three-dimensional (3D) structure and organized cell …

Regeneration of complex bone defects remains a significant clinical challenge. Multi-tool
biofabrication has permitted the combination of various biomaterials to create multifaceted …