Dendritic Cell‐Mediated Cross‐Priming by a Bispecific Neutralizing Antibody Boosts Cytotoxic T Cell Responses and Protects Mice against SARS‐CoV‐2

R Lázaro‐Gorines, P Pérez, I Heras‐Murillo… - Advanced …, 2023 - Wiley Online Library
Administration of neutralizing antibodies (nAbs) has proved to be effective by providing
immediate protection against SARS‐CoV‐2. However, dual strategies combining virus …

[HTML][HTML] A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection

G Beaudoin-Bussières, Y Chen, I Ullah, J Prévost… - Cell reports, 2022 - cell.com
Emerging evidence indicates that both neutralizing and Fc-mediated effector functions of
antibodies contribute to protection against SARS-CoV-2. It is unclear whether Fc-effector …

[HTML][HTML] Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

V Dussupt, RS Sankhala, L Mendez-Rivera… - Nature …, 2021 - nature.com
Prevention of viral escape and increased coverage against severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) variants of concern require therapeutic monoclonal …

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

L Zhang, L Cao, XS Gao, BY Zheng… - National Science …, 2021 - academic.oup.com
Mutations and transient conformational movements of the receptor binding domain (RBD)
that make neutralizing epitopes momentarily unavailable present immune escape routes for …

[HTML][HTML] Humanized single domain antibodies neutralize SARS-CoV-2 by targeting the spike receptor binding domain

X Chi, X Liu, C Wang, X Zhang, X Li, J Hou… - Nature …, 2020 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and
leads to an unprecedented medical burden and lives lost. Neutralizing antibodies provide …

[HTML][HTML] An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variants

X Chi, X Zhang, S Pan, Y Yu, Y Shi, T Lin… - Signal transduction and …, 2022 - nature.com
The wide transmission and host adaptation of SARS-CoV-2 have led to the rapid
accumulation of mutations, posing significant challenges to the effectiveness of vaccines …

Single shot dendritic cell targeting SARS-CoV-2 vaccine candidate induces broad and durable systemic and mucosal immune responses

NY Zhi Cheang, PS Tan, K Purushotorma, WC Yap… - bioRxiv, 2023 - biorxiv.org
Current COVID-19 vaccines face certain limitations, which include waning immunity,
immune escape by SARS-CoV-2 variants, limited CD8+ cellular response, and poor …

[HTML][HTML] Structure-based development of human antibody cocktails against SARS-CoV-2

N Wang, Y Sun, R Feng, Y Wang, Y Guo, L Zhang… - Cell research, 2021 - nature.com
Dear Editor, The ongoing COVID-19 pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has resulted in unprecedented public health and …

[HTML][HTML] Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

[HTML][HTML] A novel bispecific antibody dual-targeting approach for enhanced neutralization against fast-evolving SARS-CoV-2 variants

JW Kim, HJ Kim, K Heo, Y Lee, HJ Jang… - Frontiers in …, 2023 - frontiersin.org
Introduction The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) variants has caused unprecedented health and socioeconomic crises, necessitating …