Background The pygopus gene of Drosophila encodes an essential component of the
Armadillo (β-catenin) transcription factor complex of canonical Wnt signaling. To better …

Wnt signalling regulates several aspects of kidney development such as nephrogenesis,
ureteric bud branching and organisation of the collecting duct cells. We addressed the …

The mature nephron forms from a simple epithelial vesicle into an elaborate structure with
distinct regions of specialized physiological function. The molecular components driving the …

The Wnt gene family, which encodes secreted growth and differentiation factors, has been
implicated in kidney organogenesis. The Wnts control both ureteric bud development and …

Abstract Development of the metanephric kidney is a complicated process regulated by
reciprocal signals from the ureteric bud and the metanephric mesenchyme that regulate …

Several Wnt proteins are expressed in the embryonic kidney during various stages of
development. Gene knockout models and ex vivo studies have provided strong evidence …

Wnt4 and β-catenin are both required for nephrogenesis, but studies using TCF-reporter
mice suggest that canonical Wnt signaling is not activated in metanephric mesenchyme …

Wnt signal cascade is an evolutionarily conserved, developmental pathway that regulates
embryogenesis, injury repair, and pathogenesis of human diseases. It is well established …

The canonical WNT signaling pathway plays a crucial role in patterning of the embryo during
development, but little is known about the specific developmental events which are under …

Development of the metanephric kidney requires the concerted interaction of two tissues, the
epithelium of the ureteric duct and the metanephric mesenchyme. Signals from the ureter …