Immunogenic profiling of metastatic uveal melanoma discerns a potential signature related to prognosis

J Wang, M Liu, J Sun, Z Zhang - Journal of Cancer Research and Clinical …, 2024 - Springer
Background Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The
present study aimed to identify the key genes associated with UM metastasis and …

Role of gene signature regulation in tumor immune microenvironment on the mechanism of uveal melanoma metastasis

K Shi, J Tang, L Yuan, S Zhou, W Ran… - Cancer …, 2023 - content.iospress.com
BACKGROUND: Uveal melanoma (UM) is a rare but deadly cancer. The main cause of
death from UM is liver metastasis. Though the metastasis mechanism remains unclear, it is …

Integrated single-cell and transcriptome sequencing analyses develops a metastasis-based risk score system for prognosis and immunotherapy response in uveal …

S Meng, T Zhu, Z Fan, Y Cheng, Y Dong… - Frontiers in …, 2023 - frontiersin.org
Background: Uveal melanoma (UM) is the most frequent ocular neoplasm with a strong
metastatic ability. The prognostic value of metastasis-associated genes (MAGs) of UM …

Identification of a novel immune-related gene signature for prognosis and the tumor microenvironment in patients with uveal melanoma combining single-cell and bulk …

W Wang, H Zhao, S Wang - Frontiers in Immunology, 2023 - frontiersin.org
Introduction Uveal melanoma (UVM) is the most invasive intraocular malignancy in adults
with a poor prognosis. Growing evidence revealed that immune-related gene is related to …

Integrative analysis identifies key genes related to metastasis and a robust gene-based prognostic signature in uveal melanoma

S Lei, Y Zhang - BMC Medical Genomics, 2022 - Springer
Purpose Uveal melanoma (UM) is an aggressive intraocular malignancy, leading to
systemic metastasis in half of the patients. However, the mechanism of the high metastatic …

Construction and validation of a novel immunosignature for overall survival in uveal melanoma

C Gu, X Gu, Y Wang, Z Yao, C Zhou - Frontiers in Cell and …, 2021 - frontiersin.org
Objectives Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults, and immune infiltration plays a crucial role in the prognosis of UM. This study aimed …

Integrated analysis of genes associated with immune microenvironment and distant metastasis in uveal melanoma

W Zhou, J Li - Frontiers in Cell and Developmental Biology, 2022 - frontiersin.org
Inflammatory infiltration plays an essential role in the progression of tumor malignancy. The
aim of this study was to identify genes associated with inflammatory microenvironment and …

Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

Identification and validation of an immune-relevant risk signature predicting survival outcome and immune infiltration in uveal melanoma

X Sun, Q Li, G Xu - International Ophthalmology, 2023 - Springer
Purpose The current study aimed to reveal a novel immune-related signature to evaluate
immune infiltration status and the survival outcome for patients with uveal melanoma (UM) …

Identification of a prognostic six-immune-gene signature and a nomogram model for uveal melanoma

B Yang, Y Fan, R Liang, Y Wu, A Gu - BMC ophthalmology, 2023 - Springer
Background To identify an immune-related prognostic signature and find potential
therapeutic targets for uveal melanoma. Methods The RNA-sequencing data obtained from …