Cardiac imaging of aortic valve area from 26,142 UK Biobank participants reveal novel genetic associations and shared genetic comorbidity with multiple disease …
The aortic valve is an important determinant of cardiovascular physiology and anatomic
location of common human diseases. From a sample of 26,142 European-ancestry …
location of common human diseases. From a sample of 26,142 European-ancestry …
Cardiac imaging of aortic valve area from 34 287 UK Biobank participants reveals novel genetic associations and shared genetic comorbidity with multiple disease …
A Córdova-Palomera, C Tcheandjieu… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: The aortic valve is an important determinant of cardiovascular physiology and
anatomic location of common human diseases. Methods: From a sample of 34 287 white …
anatomic location of common human diseases. Methods: From a sample of 34 287 white …
Genome-wide analysis yields new loci associating with aortic valve stenosis
A Helgadottir, G Thorleifsson, S Gretarsdottir… - Nature …, 2018 - nature.com
Aortic valve stenosis (AS) is the most common valvular heart disease, and valve
replacement is the only definitive treatment. Here we report a large genome-wide …
replacement is the only definitive treatment. Here we report a large genome-wide …
Genome-wide association meta-analysis in 652,134 participants identifies 9 novel susceptibility loci for aortic stenosis
HY Chen, AM Small, C Dina, BJ Cairns… - European Heart …, 2020 - academic.oup.com
Background Aortic stenosis (AS) is the most common form of incident valvular heart disease.
While valve replacement is effective, the absence of an approved medical therapy provides …
While valve replacement is effective, the absence of an approved medical therapy provides …
High heritability of ascending aortic diameter and trans-ancestry prediction of thoracic aortic disease
Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a
leading cause of morbidity in the developed world. Here we performed automated extraction …
leading cause of morbidity in the developed world. Here we performed automated extraction …
Genome-wide association study of CMR image-based aortic stiffness in 45,789 individuals identifies loci linked with cardiovascular diseases
Background The use of artificial intelligence on large-scale cardiac magnetic resonance
(CMR) imaging data has enabled detailed characterisation of cardiac shape and function for …
(CMR) imaging data has enabled detailed characterisation of cardiac shape and function for …
A population-based phenome-wide association study of cardiac and aortic structure and function
Differences in cardiac and aortic structure and function are associated with cardiovascular
diseases and a wide range of other types of disease. Here we analyzed cardiovascular …
diseases and a wide range of other types of disease. Here we analyzed cardiovascular …
High heritability of ascending aortic diameter and multi-ethnic prediction of thoracic aortic disease
Enlargement of the aorta is an important risk factor for aortic aneurysm and dissection, a
leading cause of morbidity in the developed world. While Mendelian genetics account for a …
leading cause of morbidity in the developed world. While Mendelian genetics account for a …
Genome wide association studies on three-dimensional aortic geometric indices measured with magnetic resonance imaging
Introduction To date, three-dimensional properties of the aorta have not been
comprehensively quantified in a population level dataset, nor has there been a genome …
comprehensively quantified in a population level dataset, nor has there been a genome …
Spatially distinct genetic determinants of aortic dimensions influence risks of aneurysm and stenosis
Background The left ventricular outflow tract (LVOT) and ascending aorta are spatially
complex, with distinct pathologies and embryologic origins. Prior work examined the …
complex, with distinct pathologies and embryologic origins. Prior work examined the …