The phenotypic expression of sickle cell disease (SCD) varies greatly among patients and
longitudinally in the same patient. The phenotype influences all aspects of the life of affected …

The phenotypic expression of sickle cell anaemia varies greatly among patients and
longitudinally in the same patient. It influences all aspects of the life of affected individuals …

Sickle cell disease (SCD) is an inherited disorder of hemoglobin structure that has no
established cure in adult patients. Cure has been achieved in selected children with sickle …

Sickle cell disease is a monogenic disease that results in multi‐systemic pathology. This
newly updated chapter provides a clinically relevant overview of the pathophysiology …

Clinically sickle cell disease (SCD) is a pleiotropic genetic disorder of hemoglobin that has
profound manifestations. These include pain syndromes, anemia and its sequelae, infection …

Sickle Cell Disease (SCD) is a hereditary blood disorder caused by a mutation in the
hemoglobin-beta gene found on chromosome 11. This mutation results in the production of …

Over 70,000 people live with sickle cell disease in the United States and multitudes world
wide. About 2000 afflicted babies are born in this country each year. In African countries …

Sickle cell disease (SCD) is a heterogeneous disorder, with clinical manifestations including
chronic haemolysis, an increased susceptibility to infections and vaso-occlusive …

Sickle cell disease (SCD) is an inherited red blood cell (RBC) disorder caused by the
presence of an abnormal hemoglobin, called hemoglobin S (HbS) or sickle hemoglobin. It is …

Sickle cell disease (SCD) was the first “molecular” disease, but protean clinical
manifestations belie simple molecular origins. The abnormal biophysical characteristics of …