Immune cells are critical in promoting neuroinflammation and neuropathic pain and in
facilitating pain resolution, depending on their inflammatory and immunoregulatory cytokine …

Cytokines, essential mediators of inflammatory and immune responses, play an important
role in the pathophysiological processes associated with neuropathic pain following …

Neuroimmune–glia interactions have been implicated in the development of neuropathic
pain. Interleukin-27 (IL-27) is a cytokine that presents regulatory activity in inflammatory …

Abstract Interleukin-17 (IL-17) is involved in a wide range of inflammatory disorders and in
recruitment of inflammatory cells to injury sites. A recent study of IL-17 knock-out mice …

Neuropathic pain seriously affects people's life, but its mechanism is not clear. Interleukin-17
(IL-17) is a proinflammation cytokine and involved in pain regulation. Our previous study …

Neuroinflammation is critically involved in nerve injury-induced neuropathic pain,
characterized by local and systemic increased levels of proinflammatory cytokines …

Immunity and neuroinflammation play major roles in neuropathic pain. Spinal interleukin (IL)-
17A, as a mediator connecting innate and adaptive immunity, has been shown to be an …

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses. Here
we show that both the IL-18 and IL-18 receptor (IL-18R), which are induced in spinal dorsal …

Interleukin (IL)-17A, a recently described novel T cell cytokine, orchestrates inflammation in
a variety of immune-mediated diseases. In the present investigation, we analyzed the …

The release of inflammatory mediators from immune and glial cells either in the peripheral or
CNS may have an important role in the development of physiopathological processes such …