Method HepaRG cells were exposed to CPZ concentrations of 25, 50 and 100 μM for 24 h.
Cell viability was assessed by ATP-depletion assay (CellTiter-Glo). Assessment of …

Several factors are thought to be implicated in the occurrence of idiosyncratic adverse drug
reactions. The present work aimed to question as to whether inflammation is a determinant …

Chlorpromazine (CPZ) is a neuroleptic drug and prototype compound used to study
intrahepatic cholestasis. The exact mechanisms of CPZ induced cholestasis remain unclear …

Drugs induce cholestasis by diverse and still poorly understood mechanisms in humans.
Early hepatic effects of chlorpromazine (CPZ), a neuroleptic drug known for years to induce …

Since drug induced liver injury is difficult to predict in animal models, more representative
tests are needed to better evaluate these effects in humans. Existing in vitro systems hold …

Chlorpromazine (CPZ), a member of the largest class of first-generation antipsychotic
agents, is known to cause hepatotoxicity in the form of cholestasis and hepatocellular …

Inflammation is a major component of idiosyncratic adverse drug reactions (IADRs). To
understand the molecular mechanism of inflammation-mediated IADRs, we determined the …

Drug-induced liver injury is the most frequent reason for market withdrawal of approved
drugs, and is difficult to predict in animal models. Here, we analyzed transcriptomic data …

This study delves into the intricate mechanisms underlying drug-induced liver injury (DILI)
with a specific focus on bromfenac, the withdrawn nonsteroidal anti-inflammatory drug. DILI …

Background and aim Overdose of acetaminophen (APAP) leads to liver injury, which is one
of the most common causes of liver failure in the United States. We previously demonstrated …