Genome-wide analysis of insomnia disorder

MB Stein, MJ McCarthy, CY Chen, S Jain… - Molecular …, 2018 - nature.com
Insomnia is a worldwide problem with substantial deleterious health effects. Twin studies
have shown a heritable basis for various sleep-related traits, including insomnia, but robust …

Genome-wide analysis of insomnia in 1,331,010 individuals identifies new risk loci and functional pathways

PR Jansen, K Watanabe, S Stringer, N Skene… - Nature …, 2019 - nature.com
Insomnia is the second most prevalent mental disorder, with no sufficient treatment
available. Despite substantial heritability, insight into the associated genes and …

Genome-wide association analysis of insomnia using data from Partners Biobank

W Song, J Torous, J Kossowsky, CY Chen, H Huang… - Scientific Reports, 2020 - nature.com
Insomnia is one of the most prevalent and burdensome mental disorders worldwide,
affecting between 10–20% of adults and up to 48% of the geriatric population. It is further …

Genome-wide association analysis of insomnia complaints identifies risk genes and genetic overlap with psychiatric and metabolic traits

AR Hammerschlag, S Stringer, CA De Leeuw… - Nature …, 2017 - nature.com
Persistent insomnia is among the most frequent complaints in general practice. To identify
genetic factors for insomnia complaints, we performed a genome-wide association study …

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways

K Watanabe, PR Jansen, JE Savage, P Nandakumar… - Nature …, 2022 - nature.com
Insomnia is a heritable, highly prevalent sleep disorder for which no sufficient treatment
currently exists. Previous genome-wide association studies with up to 1.3 million subjects …

Genetic pathways to insomnia

MJ Lind, PR Gehrman - Brain sciences, 2016 - mdpi.com
This review summarizes current research on the genetics of insomnia, as genetic
contributions are thought to be important for insomnia etiology. We begin by providing an …

A genome‐wide association study of sleep habits and insomnia

EM Byrne, PR Gehrman, SE Medland… - American Journal of …, 2013 - Wiley Online Library
Several aspects of sleep behavior such as timing, duration and quality have been
demonstrated to be heritable. To identify common variants that influence sleep traits in the …

Biological and clinical insights from genetics of insomnia symptoms

JM Lane, SE Jones, HS Dashti, AR Wood, KG Aragam… - Nature …, 2019 - nature.com
Insomnia is a common disorder linked with adverse long-term medical and psychiatric
outcomes. The underlying pathophysiological processes and causal relationships of …

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

JM Lane, J Liang, I Vlasac, SG Anderson… - Nature …, 2017 - nature.com
Chronic sleep disturbances, associated with cardiometabolic diseases, psychiatric disorders
and all-cause mortality,, affect 25–30% of adults worldwide. Although environmental factors …

Using the Coriell Personalized Medicine Collaborative Data to conduct a genome‐wide association study of sleep duration

LB Scheinfeldt, N Gharani, RS Kasper… - American Journal of …, 2015 - Wiley Online Library
Sleep is critical to health and functionality, and several studies have investigated the
inherited component of insomnia and other sleep disorders using genome‐wide association …