Downregulation of microRNA‐6125 promotes colorectal cancer growth through YTHDF2‐dependent recognition of N6‐methyladenosine‐modified GSK3β

H Li, N Zhang, X Jiao, C Wang, W Sun… - Clinical and …, 2021 - Wiley Online Library
Background MicroRNAs (miRNAs), the key regulator of gene expression, and N6‐
methyladenosine (m6A) RNA modification play a significant role in tumour progression …

Upregulated miR‐1258 regulates cell cycle and inhibits cell proliferation by directly targeting E2F8 in CRC

Z Zhang, J Li, Y Huang, W Peng, W Qian, J Gu… - Cell …, 2018 - Wiley Online Library
Objectives Micro RNA s (mi RNA s) as small noncoding RNA molecules function by
regulating their target genes negatively. MiR‐1258 was widely researched in multicancers …

N (6)-methyladenosine-mediated miR-380-3p maturation and upregulation promotes cancer aggressiveness in pancreatic cancer

Z Jiang, X Song, Y Wei, Y Li, D Kong, J Sun - Bioengineered, 2022 - Taylor & Francis
ABSTRACT N (6)-methyladenosine (m6A)-modified microRNAs (miRNAs) are relevant to
cancer progression. Also, although the involvement of miR-380-3p in regulating cancer …

A positive feedback loop of lncRNA MIR31HG-miR-361-3p-YY1 accelerates colorectal cancer progression through modulating proliferation, angiogenesis, and …

T Guo, D Liu, S Peng, M Wang, Y Li - Frontiers in oncology, 2021 - frontiersin.org
Background Colorectal cancer (CRC) is a common malignant tumor with high metastatic and
recurrent rates. This study probes the effect and mechanism of long non-coding RNA …

MicroRNA-145 modulates N6-methyladenosine levels by targeting the 3′-untranslated mRNA region of the N6-methyladenosine binding YTH domain family 2 …

Z Yang, J Li, G Feng, S Gao, Y Wang, S Zhang… - Journal of Biological …, 2017 - ASBMB
N 6-Methyladenosine (m 6 A) is a prevalent modification present in the mRNAs of higher
eukaryotes. YTH domain family 2 (YTHDF2), an m 6 A" reader" protein, can recognize …

MicroRNA let-7i inhibits histone lysine demethylase KDM5B to halt esophageal cancer progression

Y Yang, W Li, B Wei, K Wu, D Liu, D Zhu… - … Therapy-Nucleic Acids, 2020 - cell.com
Recent studies have suggested that microRNA let-7i is a tumor suppressor in human
cancers, including esophageal cancer, but its underlying mechanism is not yet fully …

[HTML][HTML] MicroRNA-497 inhibits tumor growth and increases chemosensitivity to 5-fluorouracil treatment by targeting KSR1

L Wang, C Jiang, D Li, X Ge, Z Shi, C Li, X Liu, Y Yin… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the leading cancer-related causes of death in the world.
Recently, downregulation of microRNA-497 (miR-497) has been observed in CRC tissues …

[HTML][HTML] Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer

Y Nishizawa, M Konno, A Asai, J Koseki, K Kawamoto… - Oncotarget, 2018 - ncbi.nlm.nih.gov
Recent studies that have emerged on the diversity of RNA modification in tumors suggest
their eligibility as bona fide targets in diagnosis and drug discovery. N6-methyladenosine (m …

The long non‐coding RNA HCG18 promotes the growth and invasion of colorectal cancer cells through sponging miR‐1271 and upregulating MTDH/Wnt/β‐catenin

S Li, T Wu, D Zhang, X Sun… - Clinical and Experimental …, 2020 - Wiley Online Library
Long non‐coding RNAs (lncRNAs) have recently emerged as key regulators of the
occurrence and progression of various human cancers, including colorectal cancer …

[HTML][HTML] Methylation-mediated repression of microRNA-129-2 suppresses cell aggressiveness by inhibiting high mobility group box 1 in human hepatocellular …

Z Liu, C Dou, B Yao, M Xu, L Ding, Y Wang, Y Jia, Q Li… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Aberrant expression of microRNAs (miRNAs) and its dysfunction have been revealed as
crucial modulators of cancer initiation and progression. MiR-129-2 has been reported to play …