Despite recent advances in our understanding of the pathogenesis of polycystic kidney
disease (PKD), the underlying molecular mechanisms involved in cystogenesis are not fully …

Despite recent advances in understanding the pathogenesis of polycystic kidney disease
(PKD), the underlying molecular mechanisms involved in cystogenesis are not fully …

Background Netrin-1 is a laminin-related secreted protein, is highly induced after tissue
injury, and may serve as a marker of injury. However, the regulation of netrin-1 production is …

macrophage infiltration, chemokine expression and apoptosis in the kidney. However,
specific overexpression of netrin-1 in proximal tubular epithelial cells suppressed these …

The cellular hallmark of kidney repair is a rapid proliferation of renal tubular epithelial cells
ultimately leading to the restoration of nephron structure and function. Netrin-1 was …

Methods To better understand the cross-talk betweenmTORand PC, we generated an in-
house PKD mouse model, Cd79a-Cre; Tsc1ff (Cd79a-Tsc1 KO hereafter), recapitulating …

Background: Renal vascular networks are critical to maintaining fluid homeostasis. Despite
their important roles, formation and patterning of the renal endothelium and its effect on …

Acute kidney injury (AKI) is a common problem in the hospital setting and intensive care unit.
Despite improved understanding, there are no effective therapies available to treat AKI. A …

The kidneys have a high level of netrin-1 expression, which protects against some acute &
chronic kidney disorders. However, it is yet unknown how Netrin-1 affects renal proximal …

Cystic kidney disease is the progressive development of multiple fluid-filled cysts that may
severely compromise kidney functions and lead to renal failure. TNS1 (tensin-1) knockout …