Assessing pharmacokinetic differences in Caucasian and East Asian (Japanese, Chinese and Korean) populations driven by CYP2C19 polymorphism using …
Understanding the influence of ethnicity on drug exposure is key to patient safety and could
minimize repetitive clinical studies. This analysis aimed to evaluate the ability of …
minimize repetitive clinical studies. This analysis aimed to evaluate the ability of …
[HTML][HTML] Effect of co-administered inducer or inhibitor on omeprazole pharmacokinetics based on CYP2C19 genotype
C Kamiya, N Inui, A Hakamata, S Miyakawa… - Journal of …, 2019 - Elsevier
Polymorphisms of cytochrome P450 (CYP) enzymes can affect enzymatic activity, drug
metabolism and drug interactions. Although the potential for drug interactions is especially …
metabolism and drug interactions. Although the potential for drug interactions is especially …
Effects of the CYP3A5 genotype on omeprazole sulfoxidation in CYP2C19 PMs
K Sugimoto, T Uno, T Tateishi - European journal of clinical pharmacology, 2008 - Springer
Objective Omeprazole is metabolized by the two cytochrome P450 isoforms, CYP3A
(sulfoxidation) and CYP2C19 (hydroxydation). The aim of this study was to determine …
(sulfoxidation) and CYP2C19 (hydroxydation). The aim of this study was to determine …
Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenous and oral administrations
T Uno, T Niioka, M Hayakari, N Yasui-Furukori… - European journal of …, 2007 - Springer
Objective The aim of this study was to evaluate the absolute bioavailability and the
metabolism of omeprazole following single intravenous and oral administrations to healthy …
metabolism of omeprazole following single intravenous and oral administrations to healthy …
Prediction of drug‐drug interactions using physiologically‐based pharmacokinetic models of CYP450 modulators included in Simcyp software
N Marsousi, JA Desmeules, S Rudaz… - … & drug disposition, 2018 - Wiley Online Library
In recent years, physiologically based PharmacoKinetic (PBPK) modeling has received
growing interest as a useful tool for the assessment of drug pharmacokinetics. It has been …
growing interest as a useful tool for the assessment of drug pharmacokinetics. It has been …
Prediction of Omeprazole Pharmacokinetics and its Inhibition on Gastric Acid Secretion in Humans Using Physiologically Based Pharmacokinetic-Pharmacodynamic …
S Li, L Xie, L Yang, L Jiang, Y Yang, H Zhi, X Liu… - Pharmaceutical …, 2023 - Springer
Purpose To develop a whole physiologically based pharmacokinetic-pharmacodynamic
(PBPK-PD) model to describe the pharmacokinetics and anti-gastric acid secretion of …
(PBPK-PD) model to describe the pharmacokinetics and anti-gastric acid secretion of …
Differences in cytochrome p450-mediated pharmacokinetics between chinese and caucasian populations predicted by mechanistic physiologically based …
ZE Barter, GT Tucker, K Rowland-Yeo - Clinical pharmacokinetics, 2013 - Springer
Abstract Background International Conference on Harmonization of Technical Requirements
for Registration of Pharmaceuticals for Human Use (ICH) guidelines emphasize the need for …
for Registration of Pharmaceuticals for Human Use (ICH) guidelines emphasize the need for …
Evaluation of the relationship between polymorphisms in CYP2C19 and the pharmacokinetics of omeprazole, pantoprazole and rabeprazole
M Román, D Ochoa, SD Sánchez-Rojas… - …, 2014 - Future Medicine
Aim: To evaluate the possible association between polymorphisms in CYP2C19 and the
pharmacokinetics of omeprazole, rabeprazole and pantoprazole. Materials & methods: 151 …
pharmacokinetics of omeprazole, rabeprazole and pantoprazole. Materials & methods: 151 …
[HTML][HTML] Limited sampling modeling for estimation of phenotypic metrics for CYP enzymes and the ABCB1 transporter using a cocktail approach
EB Coelho, DAC Cusinato, JP Ximenez… - Frontiers in …, 2020 - frontiersin.org
Plasma concentration data points (n= 2,640) from 16 healthy adults were used to develop
and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP …
and validate limited sampling strategies (LSS) for estimation of phenotypic metrics for CYP …
[HTML][HTML] Comprehensive in vitro and in silico assessments of metabolic capabilities of 24 genomic variants of CYP2C19 using two different substrates
ME Seo, BJ Min, N Heo, KH Lee, JH Kim - Frontiers in Pharmacology, 2023 - frontiersin.org
Introduction: Most hepatically cleared drugs are metabolized by cytochromes P450 (CYPs),
and Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines provide …
and Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines provide …