Predicting the effect of cytochrome P450 inhibitors on substrate drugs: analysis of physiologically based pharmacokinetic modeling submissions to the US Food and …
Abstract Background and Objective The US Food and Drug Administration (FDA) has seen a
recent increase in the application of physiologically based pharmacokinetic (PBPK) …
recent increase in the application of physiologically based pharmacokinetic (PBPK) …
Using population pharmacokinetic analyses of drugs metabolized by CYP2D6 to study the genotype–phenotype translation
T Frederiksen - Basic & Clinical Pharmacology & Toxicology, 2023 - Wiley Online Library
Abstract Cytochrome P450 2D6 (CYP2D6) is an important drug‐metabolizing enzyme
exhibiting extensive interindividual variability predominantly caused by genetic …
exhibiting extensive interindividual variability predominantly caused by genetic …
Predicting the effect of CYP3A inducers on the pharmacokinetics of substrate drugs using physiologically based pharmacokinetic (PBPK) modeling: an analysis of …
Abstract Background and Objective We recently published analyses regarding the predictive
performance of physiologically based pharmacokinetic (PBPK) models, submitted to the US …
performance of physiologically based pharmacokinetic (PBPK) models, submitted to the US …
Development of robust quantitative structure-activity relationship models for CYP2C9, CYP2D6, and CYP3A4 catalysis and inhibition
E Gonzalez, S Jain, P Shah, N Torimoto-Katori… - Drug Metabolism and …, 2021 - ASPET
Cytochrome P450 enzymes are responsible for the metabolism of> 75% of marketed drugs,
making it essential to identify the contributions of individual cytochromes P450 to the total …
making it essential to identify the contributions of individual cytochromes P450 to the total …
Nonlinear Kinetics After High–Dose Omeprazole Caused by Saturation of Genetically Variable Cyp2c19
KL Rost, I Roots - Hepatology, 1996 - journals.lww.com
Nonlinear kinetics of omeprazole and its metabolites were investigated after treatment with
repeated high doses. Extensive metabolizers relating to cytochrome P450 2C19 (CYP2C19) …
repeated high doses. Extensive metabolizers relating to cytochrome P450 2C19 (CYP2C19) …
Quantitative prediction of the impact of drug interactions and genetic polymorphisms on cytochrome P450 2C9 substrate exposure
AC Castellan, M Tod, F Gueyffier, M Audars… - Clinical …, 2013 - Springer
Abstract Background and Objective Cytochrome P450 (CYP) 2C9 is the most common
CYP2C enzyme and makes up approximately onethird of total CYP protein content in the …
CYP2C enzyme and makes up approximately onethird of total CYP protein content in the …
Application of in vitro-in vivo extrapolation (IVIVE) and physiologically based pharmacokinetic (PBPK) modelling to investigate the impact of the CYP2C8 …
KR Yeo, JR Kenny, A Rostami-Hodjegan - European journal of clinical …, 2013 - Springer
Purpose To predict the impact of the CYP2C8* 3 genotype on rosiglitazone exposure in the
absence and presence of trimethoprim. Methods Prior in vitro and in vivo information for …
absence and presence of trimethoprim. Methods Prior in vitro and in vivo information for …
Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug
MLT Vieira, B Kirby… - Clinical …, 2014 - Wiley Online Library
Nine static models (seven basic and two mechanistic) and their respective cutoff values
used for predicting cytochrome P450 3A (CYP3A) inhibition, as recommended by the US …
used for predicting cytochrome P450 3A (CYP3A) inhibition, as recommended by the US …
Evaluation of CYP2C19 Gene Polymorphisms in Patients with Acid Peptic Disorders Treated with Esomeprazole
L Díaz-Ordóñez, D Ramírez-Montaño… - Pharmacogenomics …, 2021 - Taylor & Francis
Background CYP2C19 is a highly polymorphic gene that encodes an enzyme with the same
name and whose function is associated with the metabolism of many important drugs, such …
name and whose function is associated with the metabolism of many important drugs, such …
Physiologically based predictions of the impact of inhibition of intestinal and hepatic metabolism on human pharmacokinetics of CYP3A substrates
F Fenneteau, P Poulin, F Nekka - Journal of pharmaceutical sciences, 2010 - Elsevier
The first objective of the present study was to predict the pharmacokinetics of selected
CYP3A substrates administered at a single oral dose to human. The second objective was to …
CYP3A substrates administered at a single oral dose to human. The second objective was to …