[HTML][HTML] Ancestry effects on type 2 diabetes genetic risk inference in Hispanic/Latino populations

AT Chande, L Rishishwar, AB Conley… - BMC Medical …, 2020 - Springer
Abstract Background Hispanic/Latino (HL) populations bear a disproportionately high
burden of type 2 diabetes (T2D). The ability to predict T2D genetic risk using polygenic risk …

[HTML][HTML] Development and validation of a trans-ancestry polygenic risk score for type 2 diabetes in diverse populations

T Ge, MR Irvin, A Patki, V Srinivasasainagendra… - Genome medicine, 2022 - Springer
Abstract Background Type 2 diabetes (T2D) is a worldwide scourge caused by both genetic
and environmental risk factors that disproportionately afflicts communities of color …

A comparison of type 2 diabetes risk allele load between African Americans and European Americans

JM Keaton, JN Cooke Bailey, ND Palmer, BI Freedman… - Human genetics, 2014 - Springer
The prevalence of type 2 diabetes (T2D) is greater in populations of African descent
compared to European-descent populations. Genetic risk factors may underlie the disparity …

[PDF][PDF] Genetic discovery and risk characterization in type 2 diabetes across diverse populations

LM Polfus, BF Darst, H Highland, X Sheng… - Human Genetics and …, 2021 - cell.com
Genomic discovery and characterization of risk loci for type 2 diabetes (T2D) have been
conducted primarily in individuals of European ancestry. We conducted a multiethnic …

Consistent directions of effect for established type 2 diabetes risk variants across populations: the population architecture using Genomics and Epidemiology (PAGE) …

CA Haiman, MD Fesinmeyer, KL Spencer… - Diabetes, 2012 - Am Diabetes Assoc
Common genetic risk variants for type 2 diabetes (T2D) have primarily been identified in
populations of European and Asian ancestry. We tested whether the direction of association …

Evaluation of genome-wide association study-identified type 2 diabetes loci in African Americans

J Long, T Edwards, LB Signorello, Q Cai… - American journal of …, 2012 - academic.oup.com
Abstract Type 2 diabetes (T2D) is up to twice as prevalent among African Americans as
Caucasians. Recent genome-wide association studies (GWAS) have identified multiple …

[HTML][HTML] Genetics of type 2 diabetes: implications from large-scale studies

N DeForest, AR Majithia - Current diabetes reports, 2022 - Springer
Abstract Purpose of Review Type 2 diabetes (T2D) is a multifactorial, heritable syndrome
characterized by dysregulated glucose homeostasis that results from impaired insulin …

[HTML][HTML] Meta-analysis of genome-wide association studies in African Americans provides insights into the genetic architecture of type 2 diabetes

MCY Ng, D Shriner, BH Chen, J Li, WM Chen… - PLoS …, 2014 - journals.plos.org
Type 2 diabetes (T2D) is more prevalent in African Americans than in Europeans. However,
little is known about the genetic risk in African Americans despite the recent identification of …

[HTML][HTML] A polygenic score for type 2 diabetes improves risk stratification beyond current clinical screening factors in an ancestrally diverse sample

JR Ashenhurst, OV Sazonova, O Svrchek… - Frontiers in …, 2022 - frontiersin.org
A substantial proportion of the adult United States population with type 2 diabetes (T2D) are
undiagnosed, calling into question the comprehensiveness of current screening practices …

[HTML][HTML] Genetics of type 2 diabetes in African Americans

MCY Ng - Current diabetes reports, 2015 - Springer
Abstract Type 2 diabetes (T2D) is a global health problem showing substantial ethnic
disparity in disease prevalence. African Americans have one of the highest prevalence of …