[HTML][HTML] Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
H Shan, J Liu, J Shen, J Dai, G Xu, K Lu, C Han… - Cell chemical …, 2021 - cell.com
The COVID-19 pandemic has been disastrous to society and effective drugs are urgently
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …
needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is …
Activity profiling and structures of inhibitor-bound SARS-CoV-2-PLpro protease provides a framework for anti-COVID-19 drug design
In December 2019, the first cases of a novel coronavirus infection causing COVID-19 were
diagnosed in Wuhan, China. Viral Papain-Like cysteine protease (PLpro, NSP3) is essential …
diagnosed in Wuhan, China. Viral Papain-Like cysteine protease (PLpro, NSP3) is essential …
[HTML][HTML] Identification of SARS-CoV-2 inhibitors targeting Mpro and PLpro using in-cell-protease assay
A Narayanan, M Narwal, SA Majowicz… - Communications …, 2022 - nature.com
SARS-CoV-2 proteases Mpro and PLpro are promising targets for antiviral drug
development. In this study, we present an antiviral screening strategy involving a novel in …
development. In this study, we present an antiviral screening strategy involving a novel in …
[HTML][HTML] Potential RNA-dependent RNA polymerase inhibitors as prospective therapeutics against SARS-CoV-2
R Pokhrel, P Chapagain… - Journal of medical …, 2020 - microbiologyresearch.org
Introduction. The emergence of SARS-CoV-2 has taken humanity off guard. Following an
outbreak of SARS-CoV in 2002, and MERS-CoV about 10 years later, SARS-CoV-2 is the …
outbreak of SARS-CoV in 2002, and MERS-CoV about 10 years later, SARS-CoV-2 is the …
Potential of coronavirus 3C-like protease inhibitors for the development of new anti-SARS-CoV-2 drugs: Insights from structures of protease and inhibitors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to SARS-CoV and
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
Middle East respiratory syndrome coronavirus (MERS-CoV), which belong to the same …
A review of the latest research on M pro targeting SARS-COV inhibitors
H Yang, J Yang - RSC medicinal chemistry, 2021 - pubs.rsc.org
Since the outbreak of COVID-19, the pandemic caused by SARS-CoV-2 infection is still
spreading at an alarming rate and has caused huge loss of life and economic damage …
spreading at an alarming rate and has caused huge loss of life and economic damage …
[HTML][HTML] A review of the current landscape of SARS-CoV-2 main protease inhibitors: Have we hit the bullseye yet?
G Macip, P Garcia-Segura, J Mestres-Truyol… - International journal of …, 2021 - mdpi.com
In this review, we collected 1765 severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) M-pro inhibitors from the bibliography and other sources, such as the COVID …
CoV-2) M-pro inhibitors from the bibliography and other sources, such as the COVID …
Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
M Chien, TK Anderson, S Jockusch, C Tao… - Journal of proteome …, 2020 - ACS Publications
SARS-CoV-2 is responsible for the current COVID-19 pandemic. On the basis of our
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
analysis of hepatitis C virus and coronavirus replication, and the molecular structures and …
Identification of 14 known drugs as inhibitors of the main protease of SARS-CoV-2
MM Ghahremanpour, J Tirado-Rives… - ACS medicinal …, 2020 - ACS Publications
A consensus virtual screening protocol has been applied to ca. 2000 approved drugs to
seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID …
seek inhibitors of the main protease (Mpro) of SARS-CoV-2, the virus responsible for COVID …
Structure and function of SARS-CoV and SARS-CoV-2 main proteases and their inhibition: A comprehensive review
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) identified in 2003
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …
infected∼ 8000 people in 26 countries with 800 deaths, which was soon contained and …