CCR5Δ32 in HCV infection, HCV/HIV co-infection, and HCV-related diseases

JH Ellwanger, BK Leal, JM Valverde-Villegas… - Infection, Genetics and …, 2018 - Elsevier
Although a potential involvement of the CCR5Δ32 variant has already been suggested in
relation to susceptibility to hepatitis C virus (HCV) infection, data from the literature is still …

[HTML][HTML] Role of the genetic variant CCR5Δ32 in HBV infection and HBV/HIV co-infection

JH Ellwanger, B Kulmann-Leal, JM Wolf, RT Michita… - Virus Research, 2020 - Elsevier
CCR5 is a chemokine receptor that mediates the action of inflammatory cells, besides acting
as an HIV co-receptor. CCR5Δ32 states for a genetic variant containing a 32 base pair …

Frequency of CCR5-Δ32 deletion in human immunodeficiency virus type 1 (HIV-1) in healthy blood donors, HIV-1-exposed seronegative and HIV-1-seropositive …

EM Vissoci Reiche… - International …, 2008 - spandidos-publications.com
The frequency of CCR5-Δ32 allele in human immunodeficiency virus type 1 (HIV-1) infection
in the southern Brazilian population was determined in a cross-sectional study carried out …

Frequency of the CCR5-delta32 allele in Brazilian populations: A systematic literature review and meta-analysis

WHV Silva-Carvalho, RR de Moura… - Infection, Genetics and …, 2016 - Elsevier
The CCR5 is a chemokine receptor widely expressed by several immune cells that are
engaged in inflammatory responses. Some populations have individuals exhibiting a 32 bp …

[HTML][HTML] CCR5Δ32 mutation does not influence the susceptibility to HCV infection, severity of liver disease and response to therapy in patients with chronic hepatitis C

A Goyal, PV Suneetha, GT Kumar… - World Journal of …, 2006 - ncbi.nlm.nih.gov
AIM: To study whether CCR5Δ32 mutation was associated with viral infection and severity of
liver disease. METHODS: Two hundred and fifty two histologically proven, chronic HCV …

Analysis of CCR5‐Δ32 and CCR2‐V64I polymorphisms in a cohort of Spanish HCV patients using Real‐time Polymerase Chain Reaction and Fluorescence …

M Ruiz‐Ferrer, N Barroso, G Antinolo… - Journal of Viral …, 2004 - Wiley Online Library
Nowadays it is clear that chemokine–chemokine receptor interactions are important in
chronic hepatitis C virus (HCV) infection. The objective of the present study was to elucidate …

The CCR5-Δ32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source

C Goulding, A Murphy, G MacDonald, S Barrett… - Gut, 2005 - gut.bmj.com
Background and aims: Chemokines are small polypeptides, a major function of which is
lymphocyte recruitment and trafficking. The aim of this study was to assess the involvement …

Clinical significance of the CCR5delta32 allele in hepatitis C

I Morard, S Clément, A Calmy, A Mangia, A Cerny… - Plos one, 2014 - journals.plos.org
Background The CCR5 receptor, expressed on Th1 cells, may influence clinical outcomes of
HCV infection. We explored a possible link between a CCR5 32-base deletion …

CCR5 Δ 32 mutation is not prevalent in Iranians with chronic HBV infection

H Khorramdelazad, E Hakimizadeh… - Journal of medical …, 2013 - Wiley Online Library
CCR5 is an important chemokine receptor involved in the recruitment of specific anti‐viral
immune cells (eg, NK cells and T cytotoxic cells) to the liver. Previous studies indicated that …

CC chemokine receptor 5 Δ32 polymorphism in two independent cohorts of hepatitis C virus infected patients without hemophilia

HE Wasmuth, A Werth, T Mueller, T Berg… - Journal of molecular …, 2004 - Springer
Recently CC chemokine receptor 5 (CCR5) related immune mechanisms and a functional
mutation of the CCR5 gene have been implicated in hepatitis C virus (HCV) infection in a …