Glycolipid-enriched membrane microdomains (“rafts”) are critical sites for signal transduction
and other processes such as intracellular transport. While the participation of T-cell rafts in …

The plasma membranes of eukaryotic cells are not uniform and possess distinct cholesterol–
and sphingolipid–rich raft microdomains that are enriched in proteins known to be essential …

Detergent‐resistant membrane microdomains enriched in sphingolipids, cholesterol and
glycosylphosphatidylinositol‐anchored proteins play essential roles in T cell receptor (TCR) …

The plasma membrane of T cells is made of a combination of glycosphingolipids and protein
receptors organized in glycolipoprotein microdomains termed lipid rafts. The structural …

Engagement of immune receptors by antigen may lead to activation, cell proliferation,
differentiation and effector functions. It has recently been proposed that the initiation and …

Lipid rafts, specialized membrane microdomains enriched in sphingolipids and cholesterol,
have been shown to function as signaling platforms in T cells. Surface raft expression is …

Lipid rafts play an important role in cell signalling, cell adhesion and other cellular functions.
Compositional heterogeneity of lipid rafts provides one mechanism of how lipid rafts provide …

Raft microdomains have been shown to play a key role in T cell activation. We found that in
human T lymphocytes the formation of functional rafts at the plasma membrane was induced …

The cholesterol-rich lipid rafts on T cell membrane play important role in the formation of T
cell receptor (TCR) signalosome upon receptor ligation. Analytical studies on the kinetics of …

Lipid rafts are established as critical structures for a variety of cellular processes, including
immune cell activation. Beyond their importance for initial immune cell activation at the …