Protoporphyrin IX stimulates melanogenesis, melanocyte dendricity, and melanosome transport through the cGMP/PKG pathway

J Lv, X An, S Jiang, Y Yang, G Song… - Frontiers in …, 2020 - frontiersin.org
Protoporphyrin IX (PPIX) is a heterocyclic organic compound that is the last intermediate in
the heme biosynthetic pathway. PPIX, due to its photodynamic effects, is utilized in the …

Protoporphyrin IX-induced phototoxicity: Mechanisms and therapeutics

Z Hussain, Q Qi, J Zhu, KE Anderson, X Ma - Pharmacology & Therapeutics, 2023 - Elsevier
Protoporphyrin IX (PPIX) is an intermediate in the heme biosynthesis pathway. Abnormal
accumulation of PPIX due to certain pathological conditions such as erythropoietic …

Diphlorethohydroxycarmalol inhibits melanogenesis via protein kinase A/cAMP response element‐binding protein and extracellular signal‐regulated kinase …

Y Ding, Y Jiang, ST Im, S Myung… - Cell Biochemistry and …, 2021 - Wiley Online Library
Diphlorethohydroxycarmalol (DPHC) is a marine polyphenolic compound derived from
brown alga Ishige okamurae. A previously study has suggested that DPHC possesses …

[HTML][HTML] Enhancement of cancer-specific protoporphyrin IX fluorescence by targeting oncogenic Ras/MEK pathway

E Yoshioka, VS Chelakkot, M Licursi, SG Rutihinda… - Theranostics, 2018 - ncbi.nlm.nih.gov
Protoporphyrin IX (PpIX) is an endogenous fluorescent molecule that selectively
accumulates in cancer cells treated with the heme precursor 5-aminolevulinic acid (5-ALA) …

Pinostrobin suppresses the α-melanocyte-stimulating hormone-induced melanogenic signaling pathway

AMGK Athapaththu, SS Sanjaya, KT Lee… - International Journal of …, 2023 - mdpi.com
Pinostrobin is a dietary flavonoid found in several plants that possesses pharmacological
properties, such as anti-cancer, anti-virus, antioxidant, anti-ulcer, and anti-aromatase effects …

Amine derivatives of furocoumarin induce melanogenesis by activating Akt/GSK-3β/β-catenin signal pathway

D Zang, C Niu, HA Aisa - Drug Design, Development and Therapy, 2019 - Taylor & Francis
Background Melanogenesis, or the biosynthesis of melanin, plays a critical role in the
pigmentation of skin, hair, and eyes. Reduced melanogenesis may lead to depigmentation …

Upregulation of Mitf by Phenolic Compounds‐Rich Cymbopogon schoenanthus Treatment Promotes Melanogenesis in B16 Melanoma Cells and Human Epidermal …

MO Villareal, S Kume, M Neffati… - BioMed Research …, 2017 - Wiley Online Library
Melanin provides inherent protection against skin cancer by absorbing broad‐spectrum
radiant energy of UV radiation. Cutaneous malignant melanoma incidence has recently …

MEK reduces cancer-specific PpIX accumulation through the RSK-ABCB1 and HIF-1α-FECH axes

VS Chelakkot, K Liu, E Yoshioka, S Saha, D Xu… - Scientific reports, 2020 - nature.com
The efficacy of aminolevulinic acid (5-ALA)-based photodynamic diagnosis (5-ALA-PDD)
and photodynamic therapy (5-ALA-PDT) is dependent on 5-ALA-induced cancer-specific …

N-Methyl Protoporphyrin IX: An Understudied Porphyrin

L Xu, Q Qi, J Zhu, X Ma - Chemical research in toxicology, 2022 - ACS Publications
N-Methyl protoporphyrin IX (NmePPIX) is a derivative of protoporphyrin IX (PPIX) and the
lattice of heme. Certain xenobiotics strongly induce NmePPIX production in the liver. The …

[HTML][HTML] The iron regulatory protein can determine the effectiveness of 5-aminolevulinic acid in inducing protoporphyrin IX in human primary skin fibroblasts

C Pourzand, E Kvam, RM Tyrrell, O Reelfs - Journal of investigative …, 1999 - Elsevier
The level of endogenous photosensitiser, protoporphyrin IX (PPIX), can be enhanced in the
cells by 5-aminolevulinic acid (ALA). We investigated the effect of critical parameters such as …