It has been several decades since synaptic dysfunction was first suggested to play a role in
schizophrenia, but only in the last few years has convincing evidence been obtained as …

Many structural alterations occur in the brain in schizophrenia (see Harrison 1999, Shapiro
1993), and the prevailing hypothesis is that these are caused by an anomaly in brain …

The pathological mechanisms underlying schizophrenia are unclear. Although genetic
susceptibility factors for schizophrenia likely influence neurodevelopmental processes, the …

Growing evidence points to synaptic pathology as a core component of the pathophysiology
of schizophrenia (SZ). Significant reductions of dendritic spine density and altered …

Schizophrenia alters basic brain processes of perception, emotion, and judgment to cause
hallucinations, delusions, thought disorder, and cognitive deficits. Unlike neurodegeneration …

Clinical, epidemiological, neuroimaging and postmortem data all suggest schizophrenia is a
neurodevelopmental disorder, and that synaptic disturbances might play a critical role in …

Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a
population prevalence of∼ 1%. Previous studies have implicated synaptic dysfunction in …

Schizophrenia (SZ) is often described as a disease of neuronal connectivity. Cognitive
processes such as working memory, which are particularly dependent on the proper …

The adult human brain consists of approximately a hundred billion neurons, which are
connected via synapses. The pattern and strength of the synaptic connections are constantly …

Schizophrenia is a chronic, severe, and disabling brain disorder, with an estimated lifetime
prevalence of 0.7%. Despite its relatively low prevalence, the onset of schizophrenia usually …