Single-cell technologies have revealed the complexity of the tumour immune
microenvironment with unparalleled resolution,,,,,,,–. Most clinical strategies rely on …

Background Tumor-infiltrating leukocytes can either limit cancer growth or facilitate its
spread. Diagnostic strategies that comprehensively assess the functional complexity of …

To examine global changes in breast heterogeneity across different states, we determined
the single‐cell transcriptomes of> 340,000 cells encompassing normal breast, preneoplastic …

Tumor ecosystems are composed of multiple cell types that communicate by ligand-receptor
interactions. Targeting ligand-receptor interactions (for instance, with immune checkpoint …

Systematic interrogation of tumor-infiltrating lymphocytes is key to the development of
immunotherapies and the prediction of their clinical responses in cancers. Here, we perform …

Understanding of the factors governing immune responses in cancer remains incomplete,
limiting patient benefit. In this study, we used mass cytometry to define the systemic immune …

Background: Not all breast cancer patients benefit from neoadjuvant or adjuvant therapy,
resulting in considerable undertreatment or overtreatment. New insights into the role of …

Background Gene expression signatures indicative of tumor proliferative capacity and tumor-
immune cell interactions have emerged as principal biology-driven predictors of breast …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …

Cancers display significant heterogeneity with respect to tissue of origin, driver mutations,
and other features of the surrounding tissue. It is likely that individual tumors engage …