As interactions between the immune system and tumour cells are governed by a complex
network of cell–cell interactions, knowing the specific immune cell composition of a solid …

Background Understanding the interactions between tumor and the host immune system is
critical to finding prognostic biomarkers, reducing drug resistance, and developing new …

To gain mechanistic insights into the functions and developmental dynamics of tumor-
infiltrated immune cells, especially B-lymphocytes, here we combine single-cell RNA …

Immune responses involve coordination across cell types and tissues. However, studies in
cancer immunotherapy have focused heavily on local immune responses in the tumor …

Tissue-resident macrophages adapt to local signals within tissues to acquire specific
functions. Neoplasia transforms the tissue, raising the question as to how the environmental …

Background Breast cancer (BC) immune infiltrates play a critical role in tumor progression
and response to treatment. Besides stromal tumor infiltrating lymphocytes (sTILs) which …

T cells are central players in cancer immunotherapy. Despite much concentrated effort on
the study of tumor-infiltrating lymphocytes (TIL), such as T cells, a series of fundamental …

To elucidate the effects of neoadjuvant chemotherapy (NAC), we conduct whole
transcriptome profiling coupled with histopathology analyses of a longitudinal breast cancer …

How mixtures of immune cells associate with cancer cell phenotype and affect pathogenesis
is still unclear. In 15 breast cancer gene expression datasets, we invariably identify three …

Human T cells coordinate adaptive immunity in diverse anatomic compartments through
production of cytokines and effector molecules, but it is unclear how tissue site influences T …