Y Lavin, S Kobayashi, A Leader, ED Amir, N Elefant… - Cell, 2017 - cell.com
To guide the design of immunotherapy strategies for patients with early stage lung tumors, we developed a multiscale immune profiling strategy to map the immune landscape of early …
Single-cell RNA sequencing has enabled the decomposition of complex tissues into functionally distinct cell types. Often, investigators wish to assign cells to cell types through …
Young women with breast cancer have disproportionately poor clinical outcomes compared to their older counterparts. The underlying biological differences behind this age-dependent …
Purpose: Lymphocytic infiltration of tumors predicts improved survival in patients with breast cancer. Previous studies have suggested that this survival benefit is confined predominantly …
JM Carter, S Chumsri, DA Hinerfeld, Y Ma… - Nature …, 2023 - nature.com
The utility of spatial immunobiomarker quantitation in prognostication and therapeutic prediction is actively being investigated in triple-negative breast cancer (TNBC). Here, with …
L Zheng, S Qin, W Si, A Wang, B Xing, R Gao, X Ren… - Science, 2021 - science.org
INTRODUCTION Cancer immunotherapies that target tumor-specific T cells have benefited many cancer patients, but the clinical efficacy varies greatly among different cancer types …
Spatial variation in cellular phenotypes underlies heterogeneity in immune recognition and response to therapy in cancer and many other diseases. Spatial transcriptomics holds the …
Cancer is a heterogeneous and complex disease. Tumors are formed by cancer cells and a myriad of non-cancerous cell types that together with the extracellular matrix form the tumor …
To the Editor: Somatic recombination and accumulation of mutations in VDJ segments result in vast heterogeneity of T-cell receptor (TCR) and immunoglobulin repertoires1, 2. High …