The discovery of the molecular basis of sickle cell disease was an important landmark in
molecular medicine. The modern tools of molecular and cellular biology have refined our …

Sickle cell anemia (SCA) was first described in the Western literature more than 100 years
ago. Elucidation of its molecular basis prompted numerous biochemical and genetic studies …

Sickle cell disease is caused by an alteration in a single DNA base, but its clinical
manifestations are influenced by other genes and behavioral and environmental factors …

In the United States, sickle cell disease affects approximately 1 in 350 African-American
newborn infants each year, and approximately 72,000 individuals total. Sickle cell disease is …

The first clinical description of sickle cell anemia was published in 1910 by Herri~ k?~ who
reported some of the clinical and hematologic manifestations of the disorder in a 20-year-old …

Sickle cell disease is a systemic disorder that is caused by a mutation (Glu6Val) in the gene
that encodes β globin. The sickle hemoglobin molecule (HbS) is a tetramer of two α-globin …

Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

The phenotypic expression of sickle cell anaemia varies greatly among patients and
longitudinally in the same patient. It influences all aspects of the life of affected individuals …

Sickle cell disease and its variants constitute the most common inherited blood disorders
affecting millions of individuals worldwide. Significant information regarding the nature of the …

Sickle cell disease is an autosomal recessive, multisystem disorder, characterised by
chronic haemolytic anaemia, painful episodes of vaso-occlusion, progressive organ failure …